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ENZYME entry: EC

Accepted Name
Fluoroacetyl-CoA thioesterase.
Reaction catalysed
Fluoroacetyl-CoA + H(2)O <=> fluoroacetate + CoA
  • Fluoroacetate is extremely toxic.
  • It reacts with CoA to form fluoroacetyl-CoA, which substitutes for acetyl CoA and reacts with EC to produce fluorocitrate, a metabolite of which binds very tightly to EC and halts the TCA cycle.
  • This enzyme hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance on the organisms that produce it.
  • It has been described in the poisonous plant Dichapetalum cymosum and the bacterium Streptomyces cattleya, both of which are fluoroacetate producers.
PRIAM enzyme-specific profiles3.1.2.29
KEGG Ligand Database for Enzyme Nomenclature3.1.2.29
IUBMB Enzyme Nomenclature3.1.2.29
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