ENZYME entry: EC 220.127.116.11
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|Fluoroacetyl-CoA + H(2)O <=> fluoroacetate + CoA|
- Fluoroacetate is extremely toxic.
- It reacts with CoA to form fluoroacetyl-CoA, which substitutes for
acetyl CoA and reacts with EC 18.104.22.168 to produce fluorocitrate,
a metabolite of which binds very tightly to EC 22.214.171.124 and halts the
- This enzyme hydrolyzes fluoroacetyl-CoA before it can react with
citrate synthase, and thus confers fluoroacetate resistance on the
organisms that produce it.
- It has been described in the poisonous plant Dichapetalum cymosum and
the bacterium Streptomyces cattleya, both of which are fluoroacetate
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
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