ENZYME entry: EC 3.1.21.3
| Accepted Name |
|---|
| Type I site-specific deoxyribonuclease.
|
| Alternative Name(s) |
|---|
| Type I restriction enzyme. |
| Reaction catalysed |
|---|
| Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed |
| Comment(s) |
|---|
- Large group of enzymes that have an absolute requirement for ATP (or
dATP) and S-adenosyl-L-methionine.
- They recognize specific short DNA sequences and cleave at sites
remote from the recognition sequence.
- Multifunctional proteins which also catalyze the reactions of
EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.
- Formerly EC 3.1.24.1 and EC 3.1.24.2.
- See the REBASE database for a complete list of these enzymes:
http://rebase.neb.com/rebase/
|
| Cross-references |
|---|
| BRENDA | 3.1.21.3 |
| EC2PDB | 3.1.21.3 |
| ExplorEnz | 3.1.21.3 |
| PRIAM enzyme-specific profiles | 3.1.21.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.21.3 |
| IUBMB Enzyme Nomenclature | 3.1.21.3 |
| IntEnz | 3.1.21.3 |
| MEDLINE | Find literature relating to 3.1.21.3 |
| MetaCyc | 3.1.21.3 |
| UniProtKB/Swiss-Prot |
| Q5HJH8, HSDR_STAAC; | Q99X26, HSDR_STAAM; | Q7A801, HSDR_STAAN; |
| Q6GKB1, HSDR_STAAR; | Q6GCT1, HSDR_STAAS; | Q8NYL9, HSDR_STAAW; |
| Q5HK76, HSDR_STAEQ; | Q4A127, HSDR_STAS1; | P10486, T1R1_ECOLX; |
| Q07736, T1RA_ECOLX; | Q47281, T1RE_ECOLX; | O05052, T1RH_HAEIN; |
| Q60295, T1RH_METJA; | P08956, T1RK_ECOLI; | P17224, T1RP_ECOLX; |
| P75431, T1RX_MYCPN; | P75433, T1RY_MYCPN; |
|
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