ENZYME entry: EC 188.8.131.52
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|T(4) deoxyribonuclease II.
|T(4) endonuclease II.|
|Endonucleolytic nicking and cleavage of cytosine-containing double-stranded DNA|
- This phage T(4) enzyme is involved in degradation of host DNA.
- The enzyme primarily catalyzes nicking of the bottom strand of double
stranded DNA between the first and second base pair to the right of a
top-strand CCGC motif.
- Double-stranded breaks are produced 5- to 10-fold less frequently.
- It does not cleave the T4 native DNA, which contains
5-hydroxymethylcytosine instead of cytosine.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
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