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ENZYME entry: EC 3.1.21.8

Accepted Name
T(4) deoxyribonuclease II.
Alternative Name(s)
T(4) endonuclease II.
Reaction catalysed
Endonucleolytic nicking and cleavage of cytosine-containing double-stranded DNA
Cofactor(s)
Mg(2+).
Comment(s)
  • This phage T(4) enzyme is involved in degradation of host DNA.
  • The enzyme primarily catalyzes nicking of the bottom strand of double stranded DNA between the first and second base pair to the right of a top-strand CCGC motif.
  • Double-stranded breaks are produced 5- to 10-fold less frequently.
  • It does not cleave the T4 native DNA, which contains 5-hydroxymethylcytosine instead of cytosine.
Cross-references
BRENDA3.1.21.8
EC2PDB3.1.21.8
ExplorEnz3.1.21.8
PRIAM enzyme-specific profiles3.1.21.8
KEGG Ligand Database for Enzyme Nomenclature3.1.21.8
IUBMB Enzyme Nomenclature3.1.21.8
IntEnz3.1.21.8
MEDLINEFind literature relating to 3.1.21.8
MetaCyc3.1.21.8
UniProtKB/Swiss-Prot
P07059, END2_BPT4

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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