ID   3.1.26.12
DE   ribonuclease E.
AN   endoribonuclease E.
AN   RNase E.
CA   Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
CC   -!- RNase E is a bacterial ribonuclease that plays a role in the
CC       processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation
CC       of bulk cellular RNA, the decay of specific regulatory, messenger and
CC       structural RNAs and the control of plasmid DNA replication.
CC   -!- The enzyme binds to monophosphorylated 5' ends of substrates but
CC       exhibits sequential cleavages in the 3' to 5' direction.
CC   -!- 2'-O-methyl nucleotide substitutions at RNase E binding sites do not
CC       prevent binding but do prevent cleavage of non-modified target
CC       sequences 5' to that locus.
CC   -!- In Escherichia coli, the enzyme is found in the RNA degradosome.
CC   -!- The C-terminal half of the protein contains binding sites for the
CC       three other major degradosomal components, the DEAD-box RNA helicase
CC       Rh1B, EC 4.1.1.11 and EC 2.7.7.8.
CC   -!- Formerly EC 3.1.26.n1.
DR   P57429, RNE_BUCAI  ;  Q8K9J9, RNE_BUCAP  ;  Q89AH3, RNE_BUCBP  ;
DR   P21513, RNE_ECOLI  ;  P44443, RNE_HAEIN  ;  A0R152, RNE_MYCS2  ;
DR   P71905, RNE_MYCTU  ;  Q8YP69, RNE_NOSS1  ;  P72656, RNE_SYNY3  ;
//