ENZYME entry: EC 3.1.26.3

Accepted Name
Ribonuclease III.
Alternative Name(s)
Ribonuclease 3.
RNase III.
Reaction catalysed
Endonucleolytic cleavage to 5'-phosphomonoester
Comment(s)
  • An endoribonuclease that cleaves double-stranded RNA molecules.
  • The cleavage can be either a single-stranded nick or double-stranded break in the RNA, depending in part upon the degree of base-pairing in the region of the cleavage site.
  • Specificity is conferred by negative determinants, i.e., the presence of certain Watson-Crick base-pairs at specific positions that strongly inhibit cleavage.
  • RNase III is involved in both rRNA processing and mRNA processing and decay.
Cross-references
PROSITEPDOC00448
BRENDA3.1.26.3
EC2PDB3.1.26.3
ExplorEnz3.1.26.3
PRIAM enzyme-specific profiles3.1.26.3
KEGG Ligand Database for Enzyme Nomenclature3.1.26.3
IUBMB Enzyme Nomenclature3.1.26.3
IntEnz3.1.26.3
MEDLINEFind literature relating to 3.1.26.3
MetaCyc3.1.26.3
UniProtKB/Swiss-Prot
Q6TUI4, DICER_BOVIN;  Q25BN1, DICER_CHICK;  A0MQH0, DICER_CRIGR;  
Q6TV19, DICER_DANRE;  Q9UPY3, DICER_HUMAN;  Q8R418, DICER_MOUSE;  
B3DLA6, DICER_XENTR;  P22192, PAC1_SCHPO;  Q8Z023, RNC1_NOSS1;  
P74368, RNC1_SYNY3;  Q8YPT4, RNC2_NOSS1;  Q55637, RNC2_SYNY3;  
Q6F9C2, RNC_ACIAD;  B7GYT0, RNC_ACIB3;  B0VTM5, RNC_ACIBS;  
A3M7P2, RNC_ACIBT;  B0VCU0, RNC_ACIBY;  F0KKL2, RNC_ACICP;  
A3MZQ9, RNC_ACTP2;  B0BUA6, RNC_ACTPJ;  A6VLV8, RNC_ACTSZ;  
B9JC73, RNC_AGRRK;  Q8UGK2, RNC_AGRT5;  B9JUN7, RNC_AGRVS;  
Q0VP19, RNC_ALCBS;  Q0A8Z1, RNC_ALKEH;  B9KGT5, RNC_ANAMF;  
Q5P9U8, RNC_ANAMM;  Q2GIW0, RNC_ANAPZ;  B7GGE9, RNC_ANOFW;  
O67082, RNC_AQUAE;  A8EV88, RNC_ARCB4;  Q5P086, RNC_AROAE;  
Q2NJY3, RNC_AYWBP;  A8I3B5, RNC_AZOC5;  B6YQI6, RNC_AZOPC;  
C1DQS2, RNC_AZOVD;  A7Z4L3, RNC_BACA2;  C3P5Q0, RNC_BACAA;  
C3L778, RNC_BACAC;  Q81WI8, RNC_BACAN;  B7JJT6, RNC_BACC0;  
Q732M1, RNC_BACC1;  B7IUK8, RNC_BACC2;  C1EP73, RNC_BACC3;  
B7HDX2, RNC_BACC4;  B7HLI2, RNC_BACC7;  A7GRH9, RNC_BACCN;  
B9IVD8, RNC_BACCQ;  Q819V8, RNC_BACCR;  Q636H7, RNC_BACCZ;  
Q5LIS2, RNC_BACFN;  Q64ZV9, RNC_BACFR;  Q9KA05, RNC_BACHD;  
Q6HEW6, RNC_BACHK;  Q65JQ5, RNC_BACLD;  Q5WFM6, RNC_BACSK;  
P51833, RNC_BACSU;  Q8A2E8, RNC_BACTN;  A6KZ76, RNC_BACV8;  
A9VT87, RNC_BACWK;  A1US36, RNC_BARBK;  Q6G459, RNC_BARHE;  
Q6G082, RNC_BARQU;  A9IRN0, RNC_BART1;  Q6MLR5, RNC_BDEBA;  
Q8G7H1, RNC_BIFLO;  Q7VRR0, RNC_BLOFL;  Q492D1, RNC_BLOPB;  
Q2KWY0, RNC_BORA1;  Q0SMF0, RNC_BORAP;  Q7WD32, RNC_BORBR;  
O51648, RNC_BORBU;  Q660G7, RNC_BORGA;  Q7W5J6, RNC_BORPA;  
A9IIJ2, RNC_BORPD;  Q7VW39, RNC_BORPE;  O69161, RNC_BRADU;  
B2SAD9, RNC_BRUA1;  Q2YN02, RNC_BRUA2;  Q57E81, RNC_BRUAB;  
A9MA35, RNC_BRUC2;  C0RI03, RNC_BRUMB;  P66664, RNC_BRUME;  
B0CKY7, RNC_BRUSI;  P66665, RNC_BRUSU;  B8D951, RNC_BUCA5;  
P57346, RNC_BUCAI;  Q8K9R1, RNC_BUCAP;  B8D7F5, RNC_BUCAT;  
P59476, RNC_BUCBP;  Q057R4, RNC_BUCCC;  Q61XX9, RNC_CAEBR;  
O01326, RNC_CAEEL;  Q8R9W3, RNC_CALS4;  A8Z6F6, RNC_CAMC1;  
A7H186, RNC_CAMC5;  A0RRM7, RNC_CAMFF;  A8FNU7, RNC_CAMJ8;  
A7H5Y2, RNC_CAMJD;  Q9PM40, RNC_CAMJE;  Q5HSF8, RNC_CAMJR;  
Q3AC58, RNC_CARHZ;  B8H627, RNC_CAUCN;  Q9A805, RNC_CAUCR;  
B0T3I0, RNC_CAUSK;  A9WJ69, RNC_CHLAA;  Q5L6E3, RNC_CHLAB;  
B8GAM6, RNC_CHLAD;  Q3AQ14, RNC_CHLCH;  Q823R4, RNC_CHLCV;  
Q253V2, RNC_CHLFF;  Q9PK97, RNC_CHLMU;  Q9Z9C7, RNC_CHLPN;  
B9LB70, RNC_CHLSY;  B0B7L3, RNC_CHLT2;  Q3KM65, RNC_CHLTA;  
B0BBS8, RNC_CHLTB;  Q8KAN7, RNC_CHLTE;  O84299, RNC_CHLTR;  
Q7NWC4, RNC_CHRVO;  Q97IA4, RNC_CLOAB;  A6LSM2, RNC_CLOB8;  
B2V4D6, RNC_CLOBA;  B2TJ22, RNC_CLOBB;  B9E1G8, RNC_CLOK1;  
A5N807, RNC_CLOK5;  Q8XJN8, RNC_CLOPE;  Q895M9, RNC_CLOTE;  
Q47WP5, RNC_COLP3;  Q6NGH3, RNC_CORDI;  Q8FP16, RNC_COREF;  
Q8NNV6, RNC_CORGL;  Q4JUY7, RNC_CORJK;  B6J4J9, RNC_COXB1;  
B6IYZ9, RNC_COXB2;  A9KFA0, RNC_COXBN;  A9N942, RNC_COXBR;  
P51837, RNC_COXBU;  Q0K8N3, RNC_CUPNH;  Q46Z18, RNC_CUPPJ;  
B3R1Z9, RNC_CUPTR;  Q47EF7, RNC_DECAR;  Q3Z7Q8, RNC_DEHM1;  
Q3ZXY9, RNC_DEHMC;  A9BNJ5, RNC_DELAS;  Q310Z1, RNC_DESAG;  
Q6ANV0, RNC_DESPS;  A4J683, RNC_DESRM;  Q72C44, RNC_DESVH;  
B8DPB3, RNC_DESVM;  A8LLD9, RNC_DINSH;  A7ZQ11, RNC_ECO24;  
B7UH07, RNC_ECO27;  B7MIQ2, RNC_ECO45;  B7LDG0, RNC_ECO55;  
P0A7Y2, RNC_ECO57;  B5Z141, RNC_ECO5E;  B7NRM0, RNC_ECO7I;  
B7MYJ8, RNC_ECO81;  B7M8I0, RNC_ECO8A;  C4ZYJ0, RNC_ECOBW;  
B1XB41, RNC_ECODH;  A8A377, RNC_ECOHS;  A1AE97, RNC_ECOK1;  
Q0TES1, RNC_ECOL5;  P0A7Y1, RNC_ECOL6;  B1IVR0, RNC_ECOLC;  
P0A7Y0, RNC_ECOLI;  B7N6F5, RNC_ECOLU;  B6I5E1, RNC_ECOSE;  
B1LP80, RNC_ECOSM;  Q1R8G6, RNC_ECOUT;  C5B8Y2, RNC_EDWI9;  
Q3YQX7, RNC_EHRCJ;  Q2GFE4, RNC_EHRCR;  Q5FGH0, RNC_EHRRG;  
Q5HA74, RNC_EHRRW;  A4WDD8, RNC_ENT38;  Q82ZG1, RNC_ENTFA;  
B2VI46, RNC_ERWT9;  B7LUZ7, RNC_ESCF3;  A6GW45, RNC_FLAPJ;  
B0TXH8, RNC_FRAP2;  Q14G66, RNC_FRAT1;  A7NAR0, RNC_FRATF;  
Q2A4N2, RNC_FRATH;  B2SFY4, RNC_FRATM;  A0Q7W6, RNC_FRATN;  
Q0BN07, RNC_FRATO;  Q5NER3, RNC_FRATT;  A4IWK9, RNC_FRATW;  
Q6GZP5, RNC_FRG3G;  Q8RGX3, RNC_FUSNN;  Q5L0Q3, RNC_GEOKA;  
Q39T82, RNC_GEOMG;  Q74AX1, RNC_GEOSL;  C5D8T6, RNC_GEOSW;  
A4IM67, RNC_GEOTN;  Q7NH89, RNC_GLOVI;  Q7VL75, RNC_HAEDU;  
Q4QPN0, RNC_HAEI8;  A5UBC4, RNC_HAEIE;  A5UFI8, RNC_HAEIG;  
P44441, RNC_HAEIN;  B8F3C7, RNC_HAEPS;  Q2SL32, RNC_HAHCH;  
C4K3Z3, RNC_HAMD5;  Q17XJ6, RNC_HELAH;  Q7VIA9, RNC_HELHP;  
B0TGW4, RNC_HELMI;  B6JLQ0, RNC_HELP2;  B5Z735, RNC_HELPG;  
Q9ZLH2, RNC_HELPJ;  B2UTG4, RNC_HELPS;  P56118, RNC_HELPY;  
B0USS1, RNC_HISS2;  Q9NRR4, RNC_HUMAN;  B4U7T8, RNC_HYDS0;  
Q5R106, RNC_IDILO;  Q196V9, RNC_IIV3;  O55748, RNC_IIV6;  
Q28V23, RNC_JANSC;  B5XNH0, RNC_KLEP3;  A6TCI1, RNC_KLEP7;  
Q5FJJ7, RNC_LACAC;  B2GD42, RNC_LACF3;  Q74IP8, RNC_LACJO;  
Q9CHD0, RNC_LACLA;  A2RLZ8, RNC_LACLM;  Q030F9, RNC_LACLS;  
Q88WK0, RNC_LACPL;  A5VKP2, RNC_LACRD;  B2G826, RNC_LACRJ;  
Q1WUA0, RNC_LACS1;  Q38XR8, RNC_LACSS;  Q5X446, RNC_LEGPA;  
A5ID21, RNC_LEGPC;  Q5ZUD5, RNC_LEGPH;  Q5WVI4, RNC_LEGPL;  
Q6AFJ4, RNC_LEIXX;  Q04R64, RNC_LEPBJ;  Q053L4, RNC_LEPBL;  
Q75FW5, RNC_LEPIC;  Q8EXX3, RNC_LEPIN;  B1N016, RNC_LEUCK;  
Q03VW5, RNC_LEUMM;  Q92AK3, RNC_LISIN;  C1KWA4, RNC_LISMC;  
Q71YL2, RNC_LISMF;  B8DDU8, RNC_LISMH;  Q8Y691, RNC_LISMO;  
A0AJR0, RNC_LISW6;  A0L633, RNC_MAGSM;  Q65VN5, RNC_MANSM;  
A6VUP6, RNC_MARMS;  Q6F1N5, RNC_MESFL;  Q608M7, RNC_METCA;  
B8EK13, RNC_METSB;  Q5UQT7, RNC_MIMIV;  Q2RJX2, RNC_MOOTA;  
Q5HZJ0, RNC_MOUSE;  P66667, RNC_MYCBO;  Q2SRZ8, RNC_MYCCT;  
Q7NAZ2, RNC_MYCGA;  P47607, RNC_MYCGE;  D3FI09, RNC_MYCGF;  
D3FH24, RNC_MYCGH;  O69469, RNC_MYCLE;  Q6KHN3, RNC_MYCMO;  
Q6MTC9, RNC_MYCMS;  Q73VL8, RNC_MYCPA;  E1QCT1, RNC_MYCPB;  
P75233, RNC_MYCPN;  A0QV20, RNC_MYCS2;  Q4A589, RNC_MYCS5;  
P9WH02, RNC_MYCTO;  P9WH03, RNC_MYCTU;  Q1D5X9, RNC_MYXXD;  
B2A2N1, RNC_NATTJ;  Q5F9X7, RNC_NEIG1;  B4RJT7, RNC_NEIG2;  
C9X0M5, RNC_NEIM8;  Q9JVD3, RNC_NEIMA;  Q9K0C8, RNC_NEIMB;  
Q0AF70, RNC_NITEC;  Q820I0, RNC_NITEU;  Q3J8D5, RNC_NITOC;  
A6Q1H0, RNC_NITSB;  Q3SRB3, RNC_NITWN;  Q5YS08, RNC_NOCFA;  
Q8ER05, RNC_OCEIH;  Q04GL2, RNC_OENOB;  Q6YPW7, RNC_ONYPE;  
D4GKM1, RNC_PANAM;  Q6MEK1, RNC_PARUW;  P57805, RNC_PASMU;  
Q6D219, RNC_PECAS;  C6DC00, RNC_PECCP;  Q03FX0, RNC_PEDPA;  
Q3A4Q8, RNC_PELCD;  Q3B6L3, RNC_PELLD;  A5D1H6, RNC_PELTS;  
Q4FLS9, RNC_PELUB;  B4RCU4, RNC_PHEZH;  Q7N1X5, RNC_PHOLL;  
Q6LMS2, RNC_PHOPR;  B3R075, RNC_PHYMT;  G3XCR8, RNC_PROMA;  
B4F047, RNC_PROMH;  Q48EV3, RNC_PSE14;  A6VAK6, RNC_PSEA7;  
B7UYX2, RNC_PSEA8;  Q02HS2, RNC_PSEAB;  Q9XCX9, RNC_PSEAE;  
Q1I5V8, RNC_PSEE4;  Q4KHT1, RNC_PSEF5;  C3K6Y7, RNC_PSEFS;  
Q3IDL2, RNC_PSEHT;  A4XSC4, RNC_PSEMY;  A5W8F2, RNC_PSEP1;  
Q3KHL9, RNC_PSEPF;  B0KV27, RNC_PSEPG;  Q88MY5, RNC_PSEPK;  
B1J4E0, RNC_PSEPW;  Q87XG1, RNC_PSESM;  Q4ZPE1, RNC_PSEU2;  
Q4FUV6, RNC_PSYA2;  A1SSM8, RNC_PSYIN;  Q1LKN1, RNC_RALME;  
B2U981, RNC_RALPJ;  Q8Y0I1, RNC_RALSO;  B3PUN8, RNC_RHIE6;  
Q2KAE3, RNC_RHIEC;  Q1MJ54, RNC_RHIL3;  Q985A6, RNC_RHILO;  
B5ZW73, RNC_RHILW;  Q92R47, RNC_RHIME;  C3M8S4, RNC_RHISN;  
Q7UGZ7, RNC_RHOBA;  Q52698, RNC_RHOCA;  Q21XN1, RNC_RHOFT;  
Q6N6C1, RNC_RHOPA;  A3PGF8, RNC_RHOS1;  Q3J5W1, RNC_RHOS4;  
A4WVP5, RNC_RHOS5;  B9KSA7, RNC_RHOSK;  C3PMF3, RNC_RICAE;  
A8GM79, RNC_RICAH;  A8GYE2, RNC_RICB8;  Q1RHA2, RNC_RICBR;  
A8EXI3, RNC_RICCK;  Q92JB0, RNC_RICCN;  Q4UKA8, RNC_RICFE;  
A8F0M2, RNC_RICM5;  Q9ZE31, RNC_RICPR;  C4K1R3, RNC_RICPU;  
B0BW84, RNC_RICRO;  A8GQT8, RNC_RICRS;  Q68XY5, RNC_RICTY;  
A7NGC5, RNC_ROSCS;  Q16AI6, RNC_ROSDO;  G2SYN4, RNC_ROSHA;  
A5V230, RNC_ROSS1;  Q5LNK5, RNC_RUEPO;  Q57LD0, RNC_SALCH;  
B5QTU8, RNC_SALEP;  B5RD49, RNC_SALG2;  Q5PIG5, RNC_SALPA;  
B5BAT0, RNC_SALPK;  Q8Z4K4, RNC_SALTI;  Q56056, RNC_SALTY;  
A8GI25, RNC_SERP5;  A1S3Y1, RNC_SHEAM;  B8EBQ2, RNC_SHEB2;  
A3D1V6, RNC_SHEB5;  A6WKQ7, RNC_SHEB8;  A9L5N6, RNC_SHEB9;  
Q12KI1, RNC_SHEDO;  Q07YZ6, RNC_SHEFN;  B0TIV7, RNC_SHEHH;  
A3QBS7, RNC_SHELP;  Q8EH81, RNC_SHEON;  A8H1C7, RNC_SHEPA;  
A4Y4K4, RNC_SHEPC;  B8CQJ5, RNC_SHEPW;  A0KZN2, RNC_SHESA;  
A8FSD6, RNC_SHESH;  Q0HG98, RNC_SHESM;  Q0HSJ1, RNC_SHESR;  
A1RMC7, RNC_SHESW;  B1KI57, RNC_SHEWM;  B2TXY0, RNC_SHIB3;  
Q31XS0, RNC_SHIBS;  Q32CV4, RNC_SHIDS;  Q0T1T8, RNC_SHIF8;  
P0A7Y3, RNC_SHIFL;  Q3YYU9, RNC_SHISS;  A6U7A8, RNC_SINMW;  
Q2NS13, RNC_SODGM;  Q027L3, RNC_SOLUE;  Q1GTU3, RNC_SPHAL;  
Q53844, RNC_SPICI;  A7X1J9, RNC_STAA1;  A6U152, RNC_STAA2;  
Q2FHK5, RNC_STAA3;  Q2FZ50, RNC_STAA8;  A5ISB8, RNC_STAA9;  
Q2YXI3, RNC_STAAB;  Q5HGJ9, RNC_STAAC;  A6QGD3, RNC_STAAE;  
Q931T1, RNC_STAAM;  P66668, RNC_STAAN;  Q6GHK2, RNC_STAAR;  
Q6G9Y0, RNC_STAAS;  A8Z3R9, RNC_STAAT;  P66669, RNC_STAAW;  
B9DPJ2, RNC_STACT;  Q5HPV8, RNC_STAEQ;  Q8CPI1, RNC_STAES;  
Q4L5T5, RNC_STAHJ;  Q49X17, RNC_STAS1;  Q3K1Y2, RNC_STRA1;  
Q8E680, RNC_STRA3;  Q8E0K7, RNC_STRA5;  Q82JT9, RNC_STRAW;  
Q9ZBQ7, RNC_STRCO;  C0M8Y3, RNC_STRE4;  A8AWC2, RNC_STRGC;  
Q8DT66, RNC_STRMU;  P66670, RNC_STRP1;  Q04K72, RNC_STRP2;  
P0DF14, RNC_STRP3;  B5E4Y2, RNC_STRP4;  Q5XDA6, RNC_STRP6;  
C1C7M6, RNC_STRP7;  P66672, RNC_STRP8;  Q1JCZ9, RNC_STRPB;  
Q1JMX4, RNC_STRPC;  Q1JI19, RNC_STRPD;  Q1J7V3, RNC_STRPF;  
A2RFW8, RNC_STRPG;  B1IC43, RNC_STRPI;  B8ZJR8, RNC_STRPJ;  
Q48UR6, RNC_STRPM;  Q97QG6, RNC_STRPN;  P0DF15, RNC_STRPQ;  
B2IPN5, RNC_STRPS;  B5XKB7, RNC_STRPZ;  Q8DPJ8, RNC_STRR6;  
C0MCR4, RNC_STRS7;  A3CP46, RNC_STRSV;  Q5LZ68, RNC_STRT1;  
Q5M3S3, RNC_STRT2;  Q03K17, RNC_STRTD;  B9DRH1, RNC_STRU0;  
C1CEK4, RNC_STRZJ;  C1CKY7, RNC_STRZP;  C1CR56, RNC_STRZT;  
A6QCJ0, RNC_SULNB;  Q67PF5, RNC_SYMTH;  A0LGM1, RNC_SYNFM;  
Q0AYW0, RNC_SYNWW;  Q47S78, RNC_THEFY;  A8F397, RNC_THELT;  
Q9X0I6, RNC_THEMA;  B9K9K8, RNC_THENN;  A5IN74, RNC_THEP1;  
B1LCY9, RNC_THESQ;  Q3SH50, RNC_THIDA;  Q73NX5, RNC_TREDE;  
O83787, RNC_TREPA;  B2S448, RNC_TREPS;  F2NV13, RNC_TRES6;  
Q83I82, RNC_TROW8;  Q83FY2, RNC_TROWT;  Q9PQT8, RNC_UREPA;  
C5CSF5, RNC_VARPS;  A1WMW1, RNC_VEREI;  A5F5H8, RNC_VIBC3;  
A7MZA8, RNC_VIBCB;  Q9KPB2, RNC_VIBCH;  C3LR04, RNC_VIBCM;  
Q5E314, RNC_VIBF1;  Q87LN9, RNC_VIBPA;  B7VK79, RNC_VIBTL;  
Q8DC76, RNC_VIBVU;  Q7MHN8, RNC_VIBVY;  Q8D305, RNC_WIGBR;  
Q73FT3, RNC_WOLPM;  B3CMS0, RNC_WOLPP;  Q7M840, RNC_WOLSU;  
Q5GTI3, RNC_WOLTR;  C0R4Q8, RNC_WOLWR;  Q8PMV0, RNC_XANAC;  
Q3BVV6, RNC_XANC5;  Q4USF7, RNC_XANC8;  Q8PB52, RNC_XANCP;  
Q5H1R2, RNC_XANOR;  B2I604, RNC_XYLF2;  Q9PB98, RNC_XYLFA;  
B0U3D8, RNC_XYLFM;  Q87C06, RNC_XYLFT;  A1JKK3, RNC_YERE8;  
A7FFT9, RNC_YERP3;  Q1C555, RNC_YERPA;  Q8ZD72, RNC_YERPE;  
A9R402, RNC_YERPG;  Q1CKE4, RNC_YERPN;  A4TKX8, RNC_YERPP;  
Q667V1, RNC_YERPS;  D5BDP9, RNC_ZUNPS;  Q9Z5U2, RNC_ZYMMO;  
Q02555, RNT1_YEAST;  

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