ENZYME entry: EC 3.1.3.11

Accepted Name
Fructose-bisphosphatase.
Alternative Name(s)
Fructose 1,6-bisphosphatase.
Hexose diphosphatase.
Reaction catalysed
D-fructose 1,6-bisphosphate + H(2)O <=> D-fructose 6-phosphate + phosphate
Comment(s)
The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.
Cross-references
PROSITEPDOC00114
BRENDA3.1.3.11
EC2PDB3.1.3.11
ExplorEnz3.1.3.11
PRIAM enzyme-specific profiles3.1.3.11
KEGG Ligand Database for Enzyme Nomenclature3.1.3.11
IUBMB Enzyme Nomenclature3.1.3.11
IntEnz3.1.3.11
MEDLINEFind literature relating to 3.1.3.11
MetaCyc3.1.3.11
UniProtKB/Swiss-Prot
P65164, CYSQ_MYCBO;  P46726, CYSQ_MYCLE;  P9WKJ0, CYSQ_MYCTO;  
P9WKJ1, CYSQ_MYCTU;  B0CAD9, F16A1_ACAM1;  A5E987, F16A1_BRASB;  
B2JEJ7, F16A1_BURP8;  Q13V64, F16A1_BURXL;  Q0KCY0, F16A1_CUPNH;  
B3R3R6, F16A1_CUPTR;  Q47A13, F16A1_DECAR;  A0M0J2, F16A1_GRAFK;  
Q5V3Z1, F16A1_HALMA;  B1XZ11, F16A1_LEPCP;  A2SFV4, F16A1_METPP;  
Q1QH19, F16A1_NITHX;  A1VL56, F16A1_POLNA;  Q3IFQ5, F16A1_PSEHT;  
Q1LQ15, F16A1_RALME;  Q21YM7, F16A1_RHOFD;  A3PNY0, F16A1_RHOS1;  
Q3IYB9, F16A1_RHOS4;  A4WW38, F16A1_RHOS5;  P27994, F16A1_RHOSH;  
Q2S2I3, F16A1_SALRD;  A7IGL7, F16A1_XANP2;  B0C7G7, F16A2_ACAM1;  
A5EQ67, F16A2_BRASB;  B2JVN8, F16A2_BURP8;  Q13QU8, F16A2_BURXL;  
P19911, F16A2_CUPNH;  B3RBL3, F16A2_CUPTR;  Q479X4, F16A2_DECAR;  
A0M764, F16A2_GRAFK;  Q5V311, F16A2_HALMA;  B1Y5W3, F16A2_LEPCP;  
A2SJJ0, F16A2_METPP;  Q1QGD7, F16A2_NITHX;  A1VNR3, F16A2_POLNA;  
Q3IH61, F16A2_PSEHT;  Q1LN82, F16A2_RALME;  Q21UY4, F16A2_RHOFD;  
A3PRW1, F16A2_RHOS1;  Q3IX60, F16A2_RHOS4;  A4WZQ4, F16A2_RHOS5;  
P22780, F16A2_RHOSH;  Q2S1G3, F16A2_SALRD;  A7IL64, F16A2_XANP2;  
B2JX47, F16A3_BURP8;  P19912, F16A3_CUPNH;  A2SJK3, F16A3_METPP;  
Q3ICJ5, F16A3_PSEHT;  A6LW95, F16C1_CLOB8;  A6M220, F16C2_CLOB8;  
P25851, F16P1_ARATH;  Q3SZB7, F16P1_BOVIN;  Q07204, F16P1_BRANA;  
P09467, F16P1_HUMAN;  Q9QXD6, F16P1_MOUSE;  O64422, F16P1_ORYSJ;  
P46275, F16P1_PEA;  P00636, F16P1_PIG;  P00637, F16P1_RABIT;  
P19112, F16P1_RAT;  P09199, F16P1_SHEEP;  Q42796, F16P1_SOYBN;  
P22418, F16P1_SPIOL;  P09195, F16P1_WHEAT;  Q9MA79, F16P2_ARATH;  
Q42649, F16P2_BETVU;  Q2KJJ9, F16P2_BOVIN;  P46267, F16P2_BRANA;  
O00757, F16P2_HUMAN;  P70695, F16P2_MOUSE;  Q9XF47, F16P2_MUSAC;  
Q9SDL8, F16P2_ORYCO;  A2WXB2, F16P2_ORYSI;  Q0JHF8, F16P2_ORYSJ;  
Q8RW99, F16P2_PEA;  Q9N0J6, F16P2_RABIT;  Q9Z1N1, F16P2_RAT;  
Q43139, F16P2_SACHY;  P46276, F16P2_SOLTU;  P14766, F16P2_SPIOL;  
P97323, F16P3_MOUSE;  A1TN89, F16PA_ACIAC;  Q6F982, F16PA_ACIAD;  
B2HWU2, F16PA_ACIBC;  B0VT80, F16PA_ACIBS;  A3M7W9, F16PA_ACIBT;  
B0VDK0, F16PA_ACIBY;  A5FWQ8, F16PA_ACICJ;  B5ELA6, F16PA_ACIF5;  
A1W9H6, F16PA_ACISJ;  A3N298, F16PA_ACTP2;  B3H282, F16PA_ACTP7;  
B0BQZ1, F16PA_ACTPJ;  A6VN92, F16PA_ACTSZ;  A0KJT2, F16PA_AERHH;  
A4SM33, F16PA_AERS4;  B6EPV3, F16PA_ALISL;  Q0A5B1, F16PA_ALKEH;  
B4S2E8, F16PA_ALTMD;  B3ERE1, F16PA_AMOA5;  Q3MCI4, F16PA_ANAVT;  
A8EU55, F16PA_ARCB4;  Q5P7F8, F16PA_AROAE;  A8I541, F16PA_AZOC5;  
A1K430, F16PA_AZOSB;  C1DHU3, F16PA_AZOVD;  Q2KZ46, F16PA_BORA1;  
Q7WL20, F16PA_BORBR;  Q7W7N2, F16PA_BORPA;  A9IQQ8, F16PA_BORPD;  
Q7VZM9, F16PA_BORPE;  Q8GKS1, F16PA_BRADU;  A4YNQ7, F16PA_BRASO;  
B2SAG4, F16PA_BRUA1;  Q2YIQ9, F16PA_BRUA2;  Q578Z3, F16PA_BRUAB;  
A9MCF4, F16PA_BRUC2;  C0RM19, F16PA_BRUMB;  Q8YCV6, F16PA_BRUME;  
A5VVE8, F16PA_BRUO2;  A9WZF8, F16PA_BRUSI;  Q8FVG9, F16PA_BRUSU;  
B1YUZ7, F16PA_BURA4;  Q1BY59, F16PA_BURCA;  B1JXN8, F16PA_BURCC;  
A0K5J0, F16PA_BURCH;  B4EB94, F16PA_BURCJ;  Q0BHD7, F16PA_BURCM;  
A9AEN5, F16PA_BURM1;  A3MHJ7, F16PA_BURM7;  A2S4W0, F16PA_BURM9;  
Q62LZ0, F16PA_BURMA;  A1V6R5, F16PA_BURMS;  A3NY10, F16PA_BURP0;  
Q3JPU4, F16PA_BURP1;  A3NC72, F16PA_BURP6;  B2T699, F16PA_BURPP;  
Q63RX4, F16PA_BURPS;  Q39IJ4, F16PA_BURS3;  Q2SY57, F16PA_BURTA;  
A4JCE2, F16PA_BURVG;  A7ZCB2, F16PA_CAMC1;  A7GXH6, F16PA_CAMC5;  
A0RP36, F16PA_CAMFF;  A7I1B8, F16PA_CAMHC;  A8FLP9, F16PA_CAMJ8;  
A7H3L9, F16PA_CAMJD;  Q0PA50, F16PA_CAMJE;  A1VZI4, F16PA_CAMJJ;  
Q5HUV6, F16PA_CAMJR;  Q9A8G9, F16PA_CAUCR;  B0T0R1, F16PA_CAUSK;  
B3PGC8, F16PA_CELJU;  Q3AT00, F16PA_CHLCH;  B3EGL2, F16PA_CHLL2;  
B3QQ73, F16PA_CHLP8;  B3ELC6, F16PA_CHLPB;  A1BEB4, F16PA_CHLPD;  
B3QWF5, F16PA_CHLT3;  Q8KFG8, F16PA_CHLTE;  Q7NVB6, F16PA_CHRVO;  
A8AMG4, F16PA_CITK8;  Q47VB1, F16PA_COLP3;  A7MM48, F16PA_CROS8;  
Q46YH7, F16PA_CUPPJ;  B1WX40, F16PA_CYAA5;  Q11R22, F16PA_CYTH3;  
A9BW85, F16PA_DELAS;  C6BTU7, F16PA_DESAD;  Q30ZN0, F16PA_DESDG;  
Q72AZ9, F16PA_DESVH;  A1VD23, F16PA_DESVV;  A5EVS5, F16PA_DICNV;  
A7ZVB0, F16PA_ECO24;  Q8XCF0, F16PA_ECO57;  B5Z3I7, F16PA_ECO5E;  
B1XEL4, F16PA_ECODH;  A8A7Y7, F16PA_ECOHS;  A1AJD7, F16PA_ECOK1;  
Q0T9F7, F16PA_ECOL5;  P0A994, F16PA_ECOL6;  B1ISX3, F16PA_ECOLC;  
P0A993, F16PA_ECOLI;  B1LRB5, F16PA_ECOSM;  Q1R324, F16PA_ECOUT;  
A4W5X6, F16PA_ENT38;  B2VCY1, F16PA_ERWT9;  A5FMJ5, F16PA_FLAJ1;  
A6GWD9, F16PA_FLAPJ;  B5EFV5, F16PA_GEOBB;  B3E2M3, F16PA_GEOLS;  
Q39UC4, F16PA_GEOMG;  Q74CM2, F16PA_GEOSL;  A5G439, F16PA_GEOUR;  
Q7NGN9, F16PA_GLOVI;  Q7VN74, F16PA_HAEDU;  Q4QL80, F16PA_HAEI8;  
A5UCP1, F16PA_HAEIE;  P45292, F16PA_HAEIN;  Q2S8D3, F16PA_HAHCH;  
A1WZH0, F16PA_HALHL;  B0R3Y1, F16PA_HALS3;  Q9HRI1, F16PA_HALSA;  
Q18J03, F16PA_HALWD;  Q17V54, F16PA_HELAH;  Q7VGH7, F16PA_HELHP;  
B5Z9G5, F16PA_HELPG;  Q1CR72, F16PA_HELPH;  Q9ZJ74, F16PA_HELPJ;  
B2UVU9, F16PA_HELPS;  O25936, F16PA_HELPY;  A4G2P0, F16PA_HERAR;  
A2RQ29, F16PA_HERSE;  Q0I4Y5, F16PA_HISS1;  B0USR6, F16PA_HISS2;  
Q9LBE7, F16PA_HYDTE;  Q5QVR9, F16PA_IDILO;  A6SVE7, F16PA_JANMA;  
B5Y2X3, F16PA_KLEP3;  A6THE3, F16PA_KLEP7;  Q1MRF1, F16PA_LAWIP;  
B0SHG0, F16PA_LEPBA;  Q04T19, F16PA_LEPBJ;  Q051E1, F16PA_LEPBL;  
B0SQL1, F16PA_LEPBP;  Q72RN8, F16PA_LEPIC;  Q8F421, F16PA_LEPIN;  
Q2W3W0, F16PA_MAGSA;  Q65S38, F16PA_MANSM;  A6W2V5, F16PA_MARMS;  
A7I8R6, F16PA_METB6;  B7L270, F16PA_METC4;  A9W1C8, F16PA_METEP;  
Q1H3T1, F16PA_METFK;  Q2FM20, F16PA_METHJ;  B3DWS5, F16PA_METI4;  
A2ST39, F16PA_METLZ;  B1Z939, F16PA_METPB;  B1LUU9, F16PA_METRJ;  
B0UEK2, F16PA_METS4;  B0JH56, F16PA_MICAN;  Q3ISJ9, F16PA_NATPD;  
Q5F8C3, F16PA_NEIG1;  B4RLD4, F16PA_NEIG2;  A9LYX9, F16PA_NEIM0;  
A1IRQ3, F16PA_NEIMA;  Q9JZH1, F16PA_NEIMB;  A1KTU6, F16PA_NEIMF;  
Q0AGV1, F16PA_NITEC;  Q82WY3, F16PA_NITEU;  Q3JF33, F16PA_NITOC;  
A6Q349, F16PA_NITSB;  P37099, F16PA_NITVU;  Q3SP44, F16PA_NITWN;  
P48847, F16PA_NOSP7;  P48991, F16PA_NOSS1;  A6X307, F16PA_OCHA4;  
A1B2P8, F16PA_PARDP;  A7HYA5, F16PA_PARL1;  Q9CMA4, F16PA_PASMU;  
Q6D074, F16PA_PECAS;  Q3A5T0, F16PA_PELCD;  Q3B5N2, F16PA_PELLD;  
B4SDN7, F16PA_PELPB;  A1APW8, F16PA_PELPD;  C0QTP7, F16PA_PERMH;  
Q7MYW6, F16PA_PHOLL;  Q6LV59, F16PA_PHOPR;  B1XVF7, F16PA_POLNS;  
Q12D67, F16PA_POLSJ;  A4SWM3, F16PA_POLSQ;  B4S3F3, F16PA_PROA2;  
B4F298, F16PA_PROMH;  A4SDH2, F16PA_PROVI;  Q48PL3, F16PA_PSE14;  
Q15ZB4, F16PA_PSEA6;  A6VDM7, F16PA_PSEA7;  B7V3K3, F16PA_PSEA8;  
Q02EQ6, F16PA_PSEAB;  Q9HU73, F16PA_PSEAE;  Q1I3Q0, F16PA_PSEE4;  
Q4KJP6, F16PA_PSEF5;  C3K7D6, F16PA_PSEFS;  A4XPL2, F16PA_PSEMY;  
A5WA74, F16PA_PSEP1;  Q3KJG0, F16PA_PSEPF;  B0KM65, F16PA_PSEPG;  
Q88CY9, F16PA_PSEPK;  B1J2P7, F16PA_PSEPW;  Q87UX4, F16PA_PSESM;  
Q4ZZI0, F16PA_PSEU2;  A4VGC9, F16PA_PSEU5;  Q4FUA6, F16PA_PSYA2;  
Q1QDE0, F16PA_PSYCK;  A1T0H3, F16PA_PSYIN;  A5WGK6, F16PA_PSYWF;  
B2U8C4, F16PA_RALPJ;  Q8XXI7, F16PA_RALSO;  Q9EXV4, F16PA_RHIME;  
O34011, F16PA_RHOCB;  Q2J1K3, F16PA_RHOP2;  Q07N65, F16PA_RHOP5;  
Q6N0W5, F16PA_RHOPA;  Q213I9, F16PA_RHOPB;  Q13CA1, F16PA_RHOPS;  
B3QB72, F16PA_RHOPT;  Q2RRP2, F16PA_RHORT;  Q21L89, F16PA_SACD2;  
B5F3E2, F16PA_SALA4;  A9MEY3, F16PA_SALAR;  Q57GG7, F16PA_SALCH;  
B5FSC7, F16PA_SALDC;  B5R0U4, F16PA_SALEP;  B5R9H4, F16PA_SALG2;  
B4TFG0, F16PA_SALHS;  B4T3H9, F16PA_SALNS;  Q5PJ74, F16PA_SALPA;  
A9N548, F16PA_SALPB;  B5BKN5, F16PA_SALPK;  B4TT57, F16PA_SALSV;  
Q8Z146, F16PA_SALTI;  Q8ZK67, F16PA_SALTY;  A8G8Y2, F16PA_SERP5;  
A1S351, F16PA_SHEAM;  A3D0P6, F16PA_SHEB5;  A6WSQ6, F16PA_SHEB8;  
A9L375, F16PA_SHEB9;  Q12JW2, F16PA_SHEDO;  Q088C3, F16PA_SHEFN;  
B0TTL6, F16PA_SHEHH;  A3QAZ7, F16PA_SHELP;  Q8EAB6, F16PA_SHEON;  
A8H0H1, F16PA_SHEPA;  A4Y373, F16PA_SHEPC;  A0KSW7, F16PA_SHESA;  
A8FRF1, F16PA_SHESH;  Q0HMI8, F16PA_SHESM;  Q0HRA0, F16PA_SHESR;  
A1RNR2, F16PA_SHESW;  B1KEL4, F16PA_SHEWM;  B2TZ12, F16PA_SHIB3;  
Q31TG8, F16PA_SHIBS;  Q328V4, F16PA_SHIDS;  Q0SXH4, F16PA_SHIF8;  
P0A995, F16PA_SHIFL;  Q3YUB9, F16PA_SHISS;  P56886, F16PA_SINMW;  
Q2NW44, F16PA_SODGM;  A9G6T8, F16PA_SORC5;  B4SR24, F16PA_STRM5;  
B2FU10, F16PA_STRMK;  Q30RP0, F16PA_SULDN;  A6Q9C9, F16PA_SULNB;  
B2V6E2, F16PA_SULSY;  Q2LUC0, F16PA_SYNAS;  Q59943, F16PA_SYNE7;  
Q2JTX5, F16PA_SYNJA;  Q2JK61, F16PA_SYNJB;  B1XNG1, F16PA_SYNP2;  
Q5N163, F16PA_SYNP6;  P74324, F16PA_SYNY3;  C5BMI0, F16PA_TERTT;  
Q8DLF2, F16PA_THEEB;  Q31FI6, F16PA_THICR;  Q3SFS6, F16PA_THIDA;  
Q118F5, F16PA_TRIEI;  A1WH14, F16PA_VEREI;  A5F599, F16PA_VIBC3;  
A7MWE4, F16PA_VIBCB;  Q9KP35, F16PA_VIBCH;  C3LRK7, F16PA_VIBCM;  
Q5E887, F16PA_VIBF1;  B5FGE3, F16PA_VIBFM;  Q87SW0, F16PA_VIBPA;  
B7VKW7, F16PA_VIBSL;  Q8DE90, F16PA_VIBVU;  Q7MPD0, F16PA_VIBVY;  
Q8D275, F16PA_WIGBR;  Q7MAI9, F16PA_WOLSU;  Q8PR42, F16PA_XANAC;  
Q3BZI4, F16PA_XANC5;  Q4V0I4, F16PA_XANC8;  B0RLK6, F16PA_XANCB;  
Q8PE85, F16PA_XANCP;  P23014, F16PA_XANFL;  Q2P9K6, F16PA_XANOM;  
B2SUX7, F16PA_XANOP;  Q5H701, F16PA_XANOR;  A1JIU6, F16PA_YERE8;  
A7FMU7, F16PA_YERP3;  Q1CBY3, F16PA_YERPA;  B2K2N1, F16PA_YERPB;  
Q0WBC9, F16PA_YERPE;  A9R579, F16PA_YERPG;  Q1CEI9, F16PA_YERPN;  
A4TRK7, F16PA_YERPP;  Q66F84, F16PA_YERPS;  B1JMK6, F16PA_YERPY;  
A6TLX6, F16PC_ALKMQ;  A7ZAK3, F16PC_BACA2;  Q5LE70, F16PC_BACFN;  
Q64VB2, F16PC_BACFR;  Q45597, F16PC_BACSU;  Q8A8D9, F16PC_BACTN;  
A6L4C6, F16PC_BACV8;  Q97IR8, F16PC_CLOAB;  A7FRC9, F16PC_CLOB1;  
C3L0R6, F16PC_CLOB6;  B2V5F2, F16PC_CLOBA;  B2TNB5, F16PC_CLOBB;  
A5HZ60, F16PC_CLOBH;  C1FSJ4, F16PC_CLOBJ;  B1IF28, F16PC_CLOBK;  
A7GAS1, F16PC_CLOBL;  B1KVJ4, F16PC_CLOBM;  Q18B55, F16PC_CLOD6;  
A0PYZ1, F16PC_CLONN;  Q897W7, F16PC_CLOTE;  Q6AMN0, F16PC_DESPS;  
Q834X4, F16PC_ENTFA;  B0S0K3, F16PC_FINM2;  Q8RFB5, F16PC_FUSNN;  
Q036S2, F16PC_LACC3;  B3W9A8, F16PC_LACCB;  Q9CIU9, F16PC_LACLA;  
A2RHX9, F16PC_LACLM;  Q1WQZ0, F16PC_LACS1;  Q38UP9, F16PC_LACSS;  
Q92DI8, F16PC_LISIN;  C1L199, F16PC_LISMC;  Q721Y7, F16PC_LISMF;  
Q8Y8R5, F16PC_LISMO;  A0AGV7, F16PC_LISW6;  Q8EMI3, F16PC_OCEIH;  
A6LI52, F16PC_PARD8;  Q03HS1, F16PC_PEDPA;  B2RIZ0, F16PC_PORG3;  
Q7MW52, F16PC_PORGI;  Q21FJ6, F16PC_SACD2;  A9FZA0, F16PC_SORC5;  
A7X6K5, F16PC_STAA1;  A6U4P6, F16PC_STAA2;  Q2FDY9, F16PC_STAA3;  
Q2FVB2, F16PC_STAA8;  A5IVU3, F16PC_STAA9;  Q2YW94, F16PC_STAAB;  
Q5HD37, F16PC_STAAC;  A6QK04, F16PC_STAAE;  Q99RB9, F16PC_STAAM;  
Q7A3I5, F16PC_STAAN;  Q6GDS9, F16PC_STAAR;  Q6G6F9, F16PC_STAAS;  
A8Z3B1, F16PC_STAAT;  Q8NUT7, F16PC_STAAW;  Q5HLB1, F16PC_STAEQ;  
Q8CN27, F16PC_STAES;  Q4L907, F16PC_STAHJ;  Q4A071, F16PC_STAS1;  
A0SJA5, F16PC_STAXY;  Q3K2F6, F16PC_STRA1;  Q8E6K1, F16PC_STRA3;  
Q8E146, F16PC_STRA5;  A8AWF2, F16PC_STRGC;  A3CMR5, F16PC_STRSV;  
B9DRN4, F16PC_STRU0;  Q6RYT0, F16P_DICDI;  Q05079, F16P_KLULA;  
P09202, F16P_SCHPO;  P09201, F16P_YEAST;  B0C1Z3, FBSB1_ACAM1;  
B0BZF8, FBSB2_ACAM1;  Q3M6T3, FBSB_ANAVT;  B1WQ07, FBSB_CYAA5;  
Q7NG31, FBSB_GLOVI;  B0JKN5, FBSB_MICAN;  Q8YY12, FBSB_NOSS1;  
A3PCH5, FBSB_PROM0;  A2C1K3, FBSB_PROM1;  A8G4E5, FBSB_PROM2;  
A2CAB7, FBSB_PROM3;  A2BW64, FBSB_PROM5;  Q31BB0, FBSB_PROM9;  
Q7TVA4, FBSB_PROMA;  Q7V808, FBSB_PROMM;  Q7V1T8, FBSB_PROMP;  
A2BQQ2, FBSB_PROMS;  Q46LG3, FBSB_PROMT;  Q31QY2, FBSB_SYNE7;  
Q2JWU7, FBSB_SYNJA;  Q2JJG9, FBSB_SYNJB;  B1XLK5, FBSB_SYNP2;  
Q5N3B5, FBSB_SYNP6;  Q7U770, FBSB_SYNPX;  A5GTE9, FBSB_SYNR3;  
Q0I9I3, FBSB_SYNS3;  Q3AXK3, FBSB_SYNS9;  Q3AK74, FBSB_SYNSC;  
P73922, FBSB_SYNY3;  Q8DJE9, FBSB_THEEB;  Q117I5, FBSB_TRIEI;  
P21437, GLPX2_ECOLI;  Q03224, GLPX_BACSU;  Q6M6E7, GLPX_CORGL;  
P0A9D0, GLPX_ECOL6;  P0A9C9, GLPX_ECOLI;  P44811, GLPX_HAEIN;  
Q7U0N5, GLPX_MYCBO;  A1KHN9, GLPX_MYCBP;  C1AM93, GLPX_MYCBT;  
B8ZSG6, GLPX_MYCLB;  Q9CBH9, GLPX_MYCLE;  A5U1E6, GLPX_MYCTA;  
A5WLC4, GLPX_MYCTF;  C6DV63, GLPX_MYCTK;  P9WN20, GLPX_MYCTO;  
P9WN21, GLPX_MYCTU;  P0A9D1, GLPX_SHIFL;  

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