ID   3.1.3.36
DE   Phosphoinositide 5-phosphatase.
AN   Diphosphoinositide phosphatase.
AN   Inositol 1,4,5-triphosphate 5-phosphomonoesterase.
AN   Inositol triphosphate 5-phosphomonoesterase.
AN   IP(3) phosphatase.
AN   Phosphatidyl-inositol-bisphosphate phosphatase.
AN   Phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase.
AN   Phosphatidylinositol 4,5-bisphosphate phosphatase.
AN   Phosphatidylinositol-bisphosphatase.
AN   Polyphosphoinositol lipid 5-phosphatase.
AN   PtdIns(4,5)P(2) phosphatase.
AN   Triphosphoinositide phosphatase.
AN   Triphosphoinositide phosphomonoesterase.
AN   Type II inositol polyphosphate 5-phosphatase.
AN   Type II inositol-1,4,5-trisphosphate 5-phosphatase.
CA   1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-
CA   1D-myo-inositol 4-phosphate + phosphate.
CC   -!- These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3)
CC       and/or Ins(1,3,4,5)P(4).
CC   -!- They are a diverse family of enzymes, with differing abilities to
CC       catalyze two or more of the four reactions listed.
CC   -!- They are thought to use inositol lipids rather than inositol
CC       phosphates as substrates in vivo.
CC   -!- All of them can use either or both of PtdIns(4,5)P(2) and
CC       PtdIns(3,4,5)P(3) as substrates; this is the main property that
CC       distinguishes them from EC 3.1.3.56.
DR   P32019, I5P2_HUMAN ;  Q8K337, I5P2_MOUSE ;  P40559, INP51_YEAST;
DR   P50942, INP52_YEAST;  Q12271, INP53_YEAST;  Q08227, INP54_YEAST;
DR   Q9NRR6, INP5E_HUMAN;  Q9JII1, INP5E_MOUSE;  A0FI79, INP5E_PANTR;
DR   Q9WVR1, INP5E_RAT  ;  Q84W55, IP5P4_ARATH;  Q9SKB7, IP5PE_ARATH;
DR   Q01968, OCRL_HUMAN ;  O43001, SYJ1_SCHPO ;  Q9USQ6, SYJ2_SCHPO ;
DR   O18964, SYNJ1_BOVIN;  O43426, SYNJ1_HUMAN;  Q8CHC4, SYNJ1_MOUSE;
DR   Q62910, SYNJ1_RAT  ;  O15056, SYNJ2_HUMAN;  Q9D2G5, SYNJ2_MOUSE;
DR   O55207, SYNJ2_RAT  ;
//