ID   3.1.3.4
DE   Phosphatidate phosphatase.
AN   Lipin.
AN   Phosphatic acid phosphatase.
AN   Phosphatic acid phosphohydrolase.
AN   Phosphatidic acid phospphatase.
CA   A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol +
CA   phosphate.
CF   Magnesium.
CC   -!- This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a
CC       1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol
CC       (DAG), the substrate for de novo lipid synthesis via the Kennedy
CC       pathway and for the synthesis of triacylglycerol.
CC   -!- In lipid signaling, the enzyme generates a pool of DAG to be used for
CC       protein kinase C activation.
CC   -!- The mammalian enzymes are known as lipins.
DR   Q9UUA6, DPP1_SCHPO ;  Q05521, DPP1_YEAST ;  Q14693, LPIN1_HUMAN;
DR   Q91ZP3, LPIN1_MOUSE;  Q92539, LPIN2_HUMAN;  Q99PI5, LPIN2_MOUSE;
DR   Q9BQK8, LPIN3_HUMAN;  Q99PI4, LPIN3_MOUSE;  Q7TNN8, LPIN3_MUSSP;
DR   O88956, LPP1_CAVPO ;  O14494, LPP1_HUMAN ;  Q61469, LPP1_MOUSE ;
DR   P60588, LPP1_PIG   ;  O08564, LPP1_RAT   ;  Q04396, LPP1_YEAST ;
DR   Q2HJ61, LPP2_BOVIN ;  O43688, LPP2_HUMAN ;  Q9DAX2, LPP2_MOUSE ;
DR   Q8K593, LPP2_RAT   ;  Q3SZE3, LPP3_BOVIN ;  O14495, LPP3_HUMAN ;
DR   Q99JY8, LPP3_MOUSE ;  P97544, LPP3_RAT   ;  Q29RT8, LPPR2_BOVIN;
DR   Q96GM1, LPPR2_HUMAN;  Q8VCY8, LPPR2_MOUSE;  Q6W5G4, LPPR2_RAT  ;
DR   Q6T4P5, LPPR3_HUMAN;  Q7TPB0, LPPR3_MOUSE;  Q7TMB0, LPPR3_RAT  ;
DR   Q7Z2D5, LPPR4_HUMAN;  Q7TME0, LPPR4_MOUSE;  Q7TMB7, LPPR4_RAT  ;
DR   P32567, PAH1_YEAST ;  Q5VZY2, PPC1A_HUMAN;  Q0VBU9, PPC1A_MOUSE;
DR   Q8NEB5, PPC1B_HUMAN;  Q3UMZ3, PPC1B_MOUSE;  Q6GQ62, PPC1B_XENLA;
DR   Q9V576, WUN_DROME  ;
//