ID   3.1.3.62
DE   multiple inositol-polyphosphate phosphatase.
AN   MIPP.
AN   phytase.
CA   (1) 1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-
CA   pentakisphosphate + phosphate.
CA   (2) 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol
CA   1,2,5,6-tetrakisphosphate + phosphate.
CA   (3) 1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol
CA   1,2,6-trisphosphate + phosphate.
CA   (4) 1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-
CA   bisphosphate + phosphate.
CA   (5) 1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate
CA   + phosphate.
CC   -!- This ubiquitous enzyme degrades myo-inositol hexakisphosphate
CC       (phytate) to Ins(2,3)P2 and Ins(2)P.
CC   -!- Activities have been characterized in the yeast Saccharomyces
CC       cerevisiae, the plant Lupinus albus and the bacteria Bacillus sp. and
CC       Raoultella terrigena.
CC   -!- In mammal cells Ins(2,3)P2 and Ins(2)P are the major inositol
CC       phosphate compounds found.
CC   -!- The mammal enzyme is also active on Ins(1,3,4,5,6)P5 that is
CC       dephosphorylated to Ins(1,4,5,6)P4 and Ins(1,4,5)P3, and on 2,3-
CC       bisphospho-D-glycerate (cf. EC 3.1.3.80).
CC   -!- In addition, it acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3 in vitro
CC       (cf. EC 3.1.3.67).
CC   -!- It does not hydrolyze phosphates from the 2-positions of inositol
CC       phosphates.
CC   -!- In other organisms the degradation of phytate follows different
CC       routes. (cf. EC 3.1.3.8, EC 3.1.3.26, and EC 3.1.3.72).
DR   F1NPQ2, MINP1_CHICK;  Q54ND5, MINP1_DICDI;  Q9VV72, MINP1_DROME;
DR   Q9UNW1, MINP1_HUMAN;  Q9Z2L6, MINP1_MOUSE;  Q5R890, MINP1_PONAB;
DR   O35217, MINP1_RAT  ;
//