ID 3.1.3.78 DE phosphatidylinositol-4,5-bisphosphate 4-phosphatase. AN PtdIns-4,5-P2 4-phosphatase. CA a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + CA H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + CA phosphate. CC -!- Two pathways exist in mammalian cells to degrade 1-phosphatidyl- CC 1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2]. CC -!- One is catalyzed by this enzyme and the other by EC 3.1.3.36, where CC the product is PtdIns4P. CC -!- The enzyme from human is specific for PtdIns(4,5)P2 as substrate, CC as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, CC PtdIns5P, PtdIns4P or PtdIns3P. CC -!- In humans, the enzyme is localized to late endosomal/lysosomal CC membranes. CC -!- It can control nuclear levels of PtdIns5P and thereby control p53- CC dependent apoptosis. CC -!- Formerly EC 3.1.3.n3. DR Q07566, IPGD_SHIFL ; Q55286, IPGD_SHISO ; Q86T03, PP4P1_HUMAN; DR Q4R6W2, PP4P1_MACFA; Q3TWL2, PP4P1_MOUSE; Q5PPM8, PP4P1_RAT ; DR Q5XKA6, PP4P1_XENLA; Q3SZ48, PP4P2_BOVIN; Q8N4L2, PP4P2_HUMAN; DR Q9CZX7, PP4P2_MOUSE; Q4V888, PP4P2_RAT ; Q5EAU3, PP4P2_XENLA; DR Q6DIE4, PP4P2_XENTR; Q32PR0, T55BA_DANRE; Q66I51, T55BB_DANRE; //