ID   3.1.3.86
DE   phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
AN   SHIP.
CA   a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) +
CA   H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-
CA   bisphosphate) + phosphate.
CC   -!- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate
CC       (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively
CC       regulating the PI3K (phosphoinositide 3-kinase) pathways.
CC   -!- The enzyme also shows activity toward PtdIns(1,3,4,5)P4.
CC   -!- The enzyme is involved in several signal transduction pathways in the
CC       immune system leading to an adverse range of effects.
CC   -!- Formerly EC 3.1.3.n1.
DR   Q92562, FIG4_HUMAN ;  Q91WF7, FIG4_MOUSE ;  Q9NRR6, INP5E_HUMAN;
DR   Q9JII1, INP5E_MOUSE;  A0FI79, INP5E_PANTR;  Q9WVR1, INP5E_RAT  ;
DR   Q9BT40, INP5K_HUMAN;  Q8C5L6, INP5K_MOUSE;  Q8H0Z6, IP5P3_ARATH;
DR   Q9LR47, IP5P6_ARATH;  Q0WQ41, IP5P7_ARATH;  Q9SIS4, IP5P9_ARATH;
DR   Q5EAF2, IP5PB_ARATH;  Q9SKB7, IP5PE_ARATH;  Q84W55, IP5PF_ARATH;
DR   Q01968, OCRL_HUMAN ;  Q6NVF0, OCRL_MOUSE ;  D3ZGS3, OCRL_RAT   ;
DR   Q92835, SHIP1_HUMAN;  Q9ES52, SHIP1_MOUSE;  P97573, SHIP1_RAT  ;
DR   Q6P4S2, SHIP1_XENLA;  A0A8I3NFE2, SHIP2_CANLF;  O15357, SHIP2_HUMAN;
DR   Q6P549, SHIP2_MOUSE;  D7PF45, SHIP2_PIG  ;  Q9WVR3, SHIP2_RAT  ;
DR   Q2I6J1, SHP2A_DANRE;  Q2I6J0, SHP2B_DANRE;
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