ENZYME entry: EC 3.1.4.1
| Accepted Name |
|---|
| Phosphodiesterase I.
|
| Alternative Name(s) |
|---|
| 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I. |
| 5'-exonuclease. |
| 5'-NPDase. |
| 5'-nucleotide phosphodiesterase. |
| 5'-PDase. |
| 5'-PDE. |
| 5'-phosphodiesterase. |
| 5'NPDE. |
| Alkaline phosphodiesterase. |
| Exonuclease I. |
| Nucleotide pyrophosphatase/phosphodiesterase I. |
| Oligonucleate 5'-nucleotidohydrolase. |
| Orthophosphoric diester phosphohydrolase. |
| PDE I. |
| Phosphodiesterase. |
| Reaction catalysed |
|---|
| Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides |
| Comment(s) |
|---|
- Hydrolyzes both ribonucleotides and deoxyribonucleotides.
- Has low activity toward polynucleotides.
- A 3'-phosphate terminus on the substrate inhibits hydrolysis.
|
| Cross-references |
|---|
| BRENDA | 3.1.4.1 |
| EC2PDB | 3.1.4.1 |
| ExplorEnz | 3.1.4.1 |
| PRIAM enzyme-specific profiles | 3.1.4.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.4.1 |
| IUBMB Enzyme Nomenclature | 3.1.4.1 |
| IntEnz | 3.1.4.1 |
| MEDLINE | Find literature relating to 3.1.4.1 |
| MetaCyc | 3.1.4.1 |
| UniProtKB/Swiss-Prot |
| P22413, ENPP1_HUMAN; | P06802, ENPP1_MOUSE; | Q924C3, ENPP1_RAT; |
| P15396, ENPP3_BOVIN; | O14638, ENPP3_HUMAN; | Q6DYE8, ENPP3_MOUSE; |
| Q5R5M5, ENPP3_PONAB; | P97675, ENPP3_RAT; | D2HNY3, FAN1_AILME; |
| Q1LWH4, FAN1_DANRE; | Q9Y2M0, FAN1_HUMAN; | Q69ZT1, FAN1_MOUSE; |
| P25353, NPP1_YEAST; | P39997, NPP2_YEAST; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-