ENZYME entry: EC 3.1.4.1

Accepted Name
Phosphodiesterase I.
Alternative Name(s)
5' nucleotide phosphodiesterase/alkaline phosphodiesterase I.
5'-exonuclease.
5'-NPDase.
5'-nucleotide phosphodiesterase.
5'-PDase.
5'-PDE.
5'-phosphodiesterase.
5'NPDE.
Alkaline phosphodiesterase.
Exonuclease I.
Nucleotide pyrophosphatase/phosphodiesterase I.
Oligonucleate 5'-nucleotidohydrolase.
Orthophosphoric diester phosphohydrolase.
PDE I.
Phosphodiesterase.
Reaction catalysed
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Comment(s)
  • Hydrolyzes both ribonucleotides and deoxyribonucleotides.
  • Has low activity toward polynucleotides.
  • A 3'-phosphate terminus on the substrate inhibits hydrolysis.
Cross-references
BRENDA3.1.4.1
EC2PDB3.1.4.1
ExplorEnz3.1.4.1
PRIAM enzyme-specific profiles3.1.4.1
KEGG Ligand Database for Enzyme Nomenclature3.1.4.1
IUBMB Enzyme Nomenclature3.1.4.1
IntEnz3.1.4.1
MEDLINEFind literature relating to 3.1.4.1
MetaCyc3.1.4.1
UniProtKB/Swiss-Prot
P22413, ENPP1_HUMAN;  P06802, ENPP1_MOUSE;  Q924C3, ENPP1_RAT;  
P15396, ENPP3_BOVIN;  O14638, ENPP3_HUMAN;  Q6DYE8, ENPP3_MOUSE;  
Q5R5M5, ENPP3_PONAB;  P97675, ENPP3_RAT;  D2HNY3, FAN1_AILME;  
Q1LWH4, FAN1_DANRE;  Q9Y2M0, FAN1_HUMAN;  Q69ZT1, FAN1_MOUSE;  
P25353, NPP1_YEAST;  P39997, NPP2_YEAST;  J3SEZ3, PDE1_CROAD;  
J3SBP3, PDE2_CROAD;  

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