ENZYME entry: EC 3.1.4.14

Accepted Name
[Acyl-carrier-protein] phosphodiesterase.
Alternative Name(s)
[Acyl-carrier-protein] 4'-pantetheine-phosphohydrolase.
ACP hydrolyase.
ACP phosphodiesterase.
Reaction catalysed
Holo-[acyl-carrier-protein] + H(2)O <=> 4'-phosphopantetheine + apo-[acyl-carrier-protein]
Comment(s)
  • The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier-protein (ACP) and short- chain ACPs over the medium- and long-chain species.
  • Deletion of the gene encoding this enzyme abolishes ACP prosthetic- group turnover in vivo.
  • Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7.
Cross-references
BRENDA3.1.4.14
EC2PDB3.1.4.14
ExplorEnz3.1.4.14
PRIAM enzyme-specific profiles3.1.4.14
KEGG Ligand Database for Enzyme Nomenclature3.1.4.14
IUBMB Enzyme Nomenclature3.1.4.14
IntEnz3.1.4.14
MEDLINEFind literature relating to 3.1.4.14
MetaCyc3.1.4.14
UniProtKB/Swiss-Prot
A7ZIF6, ACPH_ECO24;  B7UJM7, ACPH_ECO27;  B7MD62, ACPH_ECO45;  
B7L637, ACPH_ECO55;  Q8XE96, ACPH_ECO57;  B5Z2W0, ACPH_ECO5E;  
B7NJ98, ACPH_ECO7I;  B7MPG5, ACPH_ECO81;  B7M3P3, ACPH_ECO8A;  
C4ZTG1, ACPH_ECOBW;  B1XEZ2, ACPH_ECODH;  A7ZX55, ACPH_ECOHS;  
Q0TKN7, ACPH_ECOL5;  Q8FKC6, ACPH_ECOL6;  B1J045, ACPH_ECOLC;  
P21515, ACPH_ECOLI;  B7N8V6, ACPH_ECOLU;  B6HZK4, ACPH_ECOSE;  
B1LJF2, ACPH_ECOSM;  A4W777, ACPH_ENT38;  Q6D857, ACPH_ERWCT;  
B7LMI3, ACPH_ESCF3;  B5Y0Y9, ACPH_KLEP3;  A6T5D6, ACPH_KLEP7;  
Q7N0I2, ACPH_PHOLL;  B5EWT7, ACPH_SALA4;  A9MM59, ACPH_SALAR;  
Q57SG0, ACPH_SALCH;  B5FKQ8, ACPH_SALDC;  B5QTF2, ACPH_SALEP;  
B5R6Q5, ACPH_SALG2;  B4T8P3, ACPH_SALHS;  B4SWP4, ACPH_SALNS;  
Q5PFT4, ACPH_SALPA;  A9MX32, ACPH_SALPB;  C0Q7S7, ACPH_SALPC;  
B5BDD0, ACPH_SALPK;  B4TZH7, ACPH_SALSV;  Q8XEZ8, ACPH_SALTI;  
Q7CR41, ACPH_SALTY;  A8GAM3, ACPH_SERP5;  B2U407, ACPH_SHIB3;  
Q325J7, ACPH_SHIBS;  Q32JF8, ACPH_SHIDS;  Q83SG7, ACPH_SHIFL;  
Q3Z505, ACPH_SHISS;  A1JNT5, ACPH_YERE8;  A7FLF7, ACPH_YERP3;  
Q8ZC31, ACPH_YERPE;  Q66DW7, ACPH_YERPS;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
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