ENZYME entry: EC 3.1.4.3

Accepted Name
Phospholipase C.
Alternative Name(s)
Clostridium oedematiens beta- and gamma-toxins.
Clostridium welchii alpha-toxin.
Lecithinase C.
Lipophosphodiesterase I.
Reaction catalysed
A phosphatidylcholine + H(2)O <=> 1,2-diacyl-sn-glycerol + phosphocholine
Cofactor(s)
Zinc.
Comment(s)
  • The bacterial enzyme also acts on sphingomyelin and phosphatidylinositol.
  • The enzyme from seminal plasma does not act on phosphatidylinositol.
Cross-references
PROSITEPDOC00357
BRENDA3.1.4.3
EC2PDB3.1.4.3
ExplorEnz3.1.4.3
PRIAM enzyme-specific profiles3.1.4.3
KEGG Ligand Database for Enzyme Nomenclature3.1.4.3
IUBMB Enzyme Nomenclature3.1.4.3
IntEnz3.1.4.3
MEDLINEFind literature relating to 3.1.4.3
MetaCyc3.1.4.3
UniProtKB/Swiss-Prot
Q04001, PHLA_MYCTU;  P95246, PHLB_MYCTU;  P0C216, PHLC1_CLOPE;  
P09598, PHLC_BACCE;  P20419, PHLC_CLOBI;  P59026, PHLC_CLOHA;  
Q46150, PHLC_CLONO;  Q0TV31, PHLC_CLOP1;  Q9RF12, PHLC_CLOPF;  
Q8VUZ6, PHLC_CLOSO;  P33378, PHLC_LISMO;  P95245, PHLC_MYCTU;  
P06200, PHLC_PSEAE;  Q2FWP1, PHLC_STAA8;  Q5HEI1, PHLC_STAAC;  
P09978, PHLC_STAAU;  P33376, PHLD_BACCE;  P0A5R9, PHLD_MYCBO;  
P0A5R8, PHLD_MYCTU;  Q9RGS8, PHLN_BURPS;  P15713, PHLN_PSEAE;  

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