ENZYME entry: EC 3.1.4.45

Accepted Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase.
Alternative Name(s)
Alpha-N-acetylglucosaminyl phosphodiesterase.
Lysosomal alpha-N-acetylglucosaminidase.
Reaction catalysed
Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H(2)O <=> N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose
Comment(s)
Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic in intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the product of EC 2.7.8.17.
Cross-references
BRENDA	3.1.4.45
EC2PDB	3.1.4.45
ExplorEnz	3.1.4.45
PRIAM enzyme-specific profiles	3.1.4.45
KEGG Ligand Database for Enzyme Nomenclature	3.1.4.45
IUBMB Enzyme Nomenclature	3.1.4.45
IntEnz	3.1.4.45
MEDLINE	Find literature relating to 3.1.4.45
MetaCyc	3.1.4.45
UniProtKB/Swiss-Prot	P68827, NAGPA_BOVIN;   Q9UK23, NAGPA_HUMAN;   Q8BJ48, NAGPA_MOUSE;

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