ID   3.1.4.50
DE   glycosylphosphatidylinositol phospholipase D.
AN   glycoprotein phospholipase D.
AN   GPI-PLD.
AN   phosphatidylinositol-glycan-specific phospholipase D.
AN   phosphatidylinositol phospholipase D.
AN   phosphatidylinositol-specific phospholipase D.
CA   an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
CA   + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a 1,2-diacyl-
CA   sn-glycero-3-phosphate + H(+).
CC   -!- This enzyme is also active when O-4 of the glucosamine is substituted
CC       by carrying the oligosaccharide that can link a protein to the
CC       structure.
CC   -!- It therefore cleaves proteins from the lipid part of the
CC       glycosylphosphatidylinositol (GPI) anchors, but does so by
CC       hydrolysis, whereas EC 4.6.1.14 does so by elimination.
CC   -!- It acts on plasma membranes only after solubilization of the
CC       substrate with detergents or solvents, but it may act on
CC       intracellular membranes.
DR   P80109, PHLD_BOVIN ;  P80108, PHLD_HUMAN ;  O70362, PHLD_MOUSE ;
DR   Q8R2H5, PHLD_RAT   ;  Q86AV9, PLDG_DICDI ;
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