ENZYME entry: EC 3.1.8.1

Accepted Name
Aryldialkylphosphatase.
Alternative Name(s)
A-esterase.
Aryltriphosphatase.
Paraoxon hydrolase.
Paraoxonase.
Phosphotriesterase.
Reaction catalysed
An aryl dialkyl phosphate + H(2)O <=> dialkyl phosphate + an aryl alcohol
Cofactor(s)
Divalent cation.
Comment(s)
  • Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids.
  • Inhibited by chelating agents.
  • Previously regarded as identical with EC 3.1.1.2.
Cross-references
PROSITEPDOC01026
BRENDA3.1.8.1
EC2PDB3.1.8.1
ExplorEnz3.1.8.1
PRIAM enzyme-specific profiles3.1.8.1
KEGG Ligand Database for Enzyme Nomenclature3.1.8.1
IUBMB Enzyme Nomenclature3.1.8.1
IntEnz3.1.8.1
MEDLINEFind literature relating to 3.1.8.1
MetaCyc3.1.8.1
UniProtKB/Swiss-Prot
P0A434, OPD_BREDI;  P0A433, OPD_SPHSA;  Q44238, PEPQ_ALTSX;  
Q97VT7, PHP_SULSO;  P27169, PON1_HUMAN;  P52430, PON1_MOUSE;  
P27170, PON1_RABIT;  P55159, PON1_RAT;  Q90952, PON2_CHICK;  
Q91090, PON2_MELGA;  Q15166, PON3_HUMAN;  Q62087, PON3_MOUSE;  
Q9BGN0, PON3_RABIT;  Q68FP2, PON3_RAT;  

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