ENZYME entry: EC 3.11.1.1

Accepted Name
Phosphonoacetaldehyde hydrolase.
Alternative Name(s)
2-phosphonoacetylaldehyde phosphonohydrolase.
Phosphonatase.
Phosphonoacetylaldehyde phosphonohydrolase.
Reaction catalysed
Phosphonoacetaldehyde + H(2)O <=> acetaldehyde + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken.
  • The mechanism is similar to that used by EC 4.1.2.13 to break a C-C bond.
Cross-references
BRENDA3.11.1.1
EC2PDB3.11.1.1
ExplorEnz3.11.1.1
PRIAM enzyme-specific profiles3.11.1.1
KEGG Ligand Database for Enzyme Nomenclature3.11.1.1
IUBMB Enzyme Nomenclature3.11.1.1
IntEnz3.11.1.1
MEDLINEFind literature relating to 3.11.1.1
MetaCyc3.11.1.1
UniProtKB/Swiss-Prot
Q183T0, PHNXW_PEPD6;  A0KJM0, PHNX_AERHH;  B6ES82, PHNX_ALISL;  
A0RBE8, PHNX_BACAH;  Q81TE1, PHNX_BACAN;  B7JFQ8, PHNX_BACC0;  
Q73BH9, PHNX_BACC1;  B7IN18, PHNX_BACC2;  B7HH80, PHNX_BACC4;  
B7HK47, PHNX_BACC7;  O31156, PHNX_BACCE;  A7GML9, PHNX_BACCN;  
B9IUR5, PHNX_BACCQ;  Q81G82, PHNX_BACCR;  Q63E46, PHNX_BACCZ;  
Q5L9P9, PHNX_BACFN;  Q64PZ2, PHNX_BACFR;  Q6HLM1, PHNX_BACHK;  
A9VKQ2, PHNX_BACWK;  Q2L1W2, PHNX_BORA1;  Q7WL48, PHNX_BORBR;  
Q7W7R1, PHNX_BORPA;  Q7VWH8, PHNX_BORPE;  Q13YI8, PHNX_BURXL;  
B8DKP2, PHNX_DESVM;  Q2SHM4, PHNX_HAHCH;  A6TFW3, PHNX_KLEP7;  
Q88YN8, PHNX_LACPL;  Q38V12, PHNX_LACSS;  B1HPR7, PHNX_LYSSC;  
A6LFV1, PHNX_PARD8;  B2T4N1, PHNX_PARPJ;  A6V8P9, PHNX_PSEA7;  
B7UVR5, PHNX_PSEA8;  Q02JF2, PHNX_PSEAB;  Q9I433, PHNX_PSEAE;  
Q1I7T9, PHNX_PSEE4;  Q4K9L7, PHNX_PSEF5;  C3JYI3, PHNX_PSEFS;  
A5W696, PHNX_PSEP1;  Q3K9Y2, PHNX_PSEPF;  Q88KT1, PHNX_PSEPK;  
Q8RSQ3, PHNX_PSEPU;  B1JBM6, PHNX_PSEPW;  A1SY91, PHNX_PSYIN;  
B5EXH2, PHNX_SALA4;  Q57SD2, PHNX_SALCH;  B5FKT7, PHNX_SALDC;  
B5QTI0, PHNX_SALEP;  B5R6T3, PHNX_SALG2;  B4T9C7, PHNX_SALHS;  
B4SWS4, PHNX_SALNS;  Q5PFR1, PHNX_SALPA;  A9MWZ8, PHNX_SALPB;  
C0Q7V6, PHNX_SALPC;  B5BDA0, PHNX_SALPK;  B4TMB2, PHNX_SALSV;  
Q8Z8W5, PHNX_SALTI;  Q7ZAP3, PHNX_SALTY;  A0LMC1, PHNX_SYNFM;  
A5F051, PHNX_VIBC3;  A7N333, PHNX_VIBCB;  Q9KLY5, PHNX_VIBCH;  
C3LVM1, PHNX_VIBCM;  Q87JL6, PHNX_VIBPA;  Q8D3M6, PHNX_VIBVU;  
Q7MF46, PHNX_VIBVY;  

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