ID   3.2.1.106
DE   mannosyl-oligosaccharide glucosidase.
AN   Glc3Man9NAc2 oligosaccharide glucosidase.
AN   processing A-glucosidase I.
CA   H2O + N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-
CA   alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-
CA   (1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-
CA   D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-
CA   asparaginyl-[protein] = beta-D-glucose + N(4)-(alpha-D-Glc-(1->3)-alpha-
CA   D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-
CA   [alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-
CA   (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-
CA   D-GlcNAc)-L-asparaginyl-[protein].
CC   -!- This enzyme catalyzes the first step in the processing of the
CC       N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes
CC       place in the endoplasmic reticulum, by removing the distal alpha-1,2-
CC       linked glucose residue.
CC   -!- This and subsequent processing steps are required before complex
CC       N-glycans can be synthesized.
DR   P53008, CWH41_YEAST;  F4HTM3, GCS1_ARATH ;  O14255, GCS1_SCHPO ;
DR   Q19426, MOGS1_CAEEL;  Q13724, MOGS_HUMAN ;  Q80UM7, MOGS_MOUSE ;
DR   O88941, MOGS_RAT   ;
//