ID   3.2.1.113
DE   mannosyl-oligosaccharide 1,2-alpha-mannosidase.
AN   Man9-mannosidase.
AN   ManI.
AN   mannosidase 1A.
AN   mannosidase 1B.
CA   (1) 4 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-
CA   (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-
CA   D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-
CA   beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer
CA   9A1,2,3B1,2,3) = 4 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-
CA   Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-
CA   beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan
CA   mannose isomer 5A1,2).
CA   (2) 3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-
CA   (1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-
CA   D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-
CA   asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-
CA   mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-
CA   (1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-
CA   D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2).
CC   -!- This family of mammalian enzymes, located in the Golgi system,
CC       participates in the maturation process of N-glycans that leads to
CC       formation of hybrid and complex structures.
CC   -!- The enzymes catalyze the hydrolysis of the four (1->2)-linked alpha-
CC       D-mannose residues from the Man9GlcNAc2 oligosaccharide attached to
CC       target proteins.
CC   -!- Alternatively, the enzymes act on the Man8GlcNAc2 isomer formed by
CC       EC 3.2.1.209.
CC   -!- The enzymes are type II membrane proteins, require Ca(2+), and use an
CC       inverting mechanism.
CC   -!- While all three human enzymes can catalyze the reactions listed here,
CC       some of the enzymes can additionally catalyze hydrolysis in an
CC       alternative order, generating additional isomeric intermediates,
CC       although the final product is the same.
CC   -!- The names of the isomers listed here are based on a nomenclature
CC       system proposed by Prien et al.
DR   Q9BZQ6, EDEM3_HUMAN;  Q2HXL6, EDEM3_MOUSE;  Q6GQB9, EDEM3_XENLA;
DR   P53624, MA1A1_DROME;  P33908, MA1A1_HUMAN;  P45700, MA1A1_MOUSE;
DR   O02773, MA1A1_PIG  ;  P45701, MA1A1_RABIT;  O18498, MA1A1_SPOFR;
DR   O60476, MA1A2_HUMAN;  P39098, MA1A2_MOUSE;  Q9UKM7, MA1B1_HUMAN;
DR   A2AJ15, MA1B1_MOUSE;  B2GUY0, MA1B1_RAT  ;  Q9NR34, MA1C1_HUMAN;
DR   Q18788, MAN12_CAEEL;  P31723, MAN12_PENCI;  D4AV26, MNS1B_ARTBC;
DR   A1CP08, MNS1B_ASPCL;  B0XMT4, MNS1B_ASPFC;  B8N417, MNS1B_ASPFN;
DR   Q4WRZ5, MNS1B_ASPFU;  A2QAS2, MNS1B_ASPNC;  Q2ULB2, MNS1B_ASPOR;
DR   Q12563, MNS1B_ASPPH;  Q0D076, MNS1B_ASPTN;  E9CXX8, MNS1B_COCPS;
DR   Q5BF93, MNS1B_EMENI;  A1D1W1, MNS1B_NEOFI;  Q9C512, MNS1_ARATH ;
DR   Q8J0Q0, MNS1_CANAX ;  Q9P7C3, MNS1_SCHPO ;  P32906, MNS1_YEAST ;
DR   Q8H116, MNS2_ARATH ;  Q93Y37, MNS3_ARATH ;
//