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ENZYME entry: EC 184.108.40.206
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|Endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan|
- Heparanase cleaves the linkage between a glucuronic acid unit and an
N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo
- Heparanase-1 cuts macromolecular heparin into fragments of 5000-20000
- The enzyme cleaves the heparan sulfate glycosaminoglycans from
proteoglycan core proteins and degrades them to small
- Inside cells, the enzyme is important for the normal catabolism of
heparan sulfate proteoglycans, generating glycosaminoglycan fragments
that are then transported to lysosomes and completely degraded.
- When secreted, heparanase degrades basement membrane heparan sulfate
glycosaminoglycans at sites of injury or inflammation, allowing
extravasion of immune cells into nonvascular spaces and releasing
factors that regulate cell proliferation and angiogenesis.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
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