ID   3.2.1.166
DE   heparanase.
AN   Hpa1 heparanase.
AN   HPSE.
CA   endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate
CA   chains in heparan sulfate proteoglycan.
CC   -!- Heparanase cleaves the linkage between a glucuronic acid unit and an
CC       N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo
CC       group.
CC   -!- Heparanase-1 cuts macromolecular heparin into fragments of 5000-20000
CC       Da.
CC   -!- The enzyme cleaves the heparan sulfate glycosaminoglycans from
CC       proteoglycan core proteins and degrades them to small
CC       oligosaccharides.
CC   -!- Inside cells, the enzyme is important for the normal catabolism of
CC       heparan sulfate proteoglycans, generating glycosaminoglycan fragments
CC       that are then transported to lysosomes and completely degraded.
CC   -!- When secreted, heparanase degrades basement membrane heparan sulfate
CC       glycosaminoglycans at sites of injury or inflammation, allowing
CC       extravasion of immune cells into nonvascular spaces and releasing
CC       factors that regulate cell proliferation and angiogenesis.
DR   Q9MYY0, HPSE_BOVIN ;  Q90YK5, HPSE_CHICK ;  Q9Y251, HPSE_HUMAN ;
DR   Q6YGZ1, HPSE_MOUSE ;  Q71RP1, HPSE_RAT   ;
//