ENZYME entry: EC 3.2.1.169

Accepted Name
Protein O-GlcNAcase.
Alternative Name(s)
Glycoside hydrolase O-GlcNAcase.
O-GlcNAc hydrolase.
O-GlcNAcase.
OGA.
Reaction catalysed
[Protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine + H(2)O <=> [protein]-L-serine + N-acetyl-D-glucosamine [Protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine + H(2)O <=> [protein]-L-threonine + N-acetyl-D-glucosamine
Comment(s)
Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
Cross-references
BRENDA	3.2.1.169
EC2PDB	3.2.1.169
ExplorEnz	3.2.1.169
PRIAM enzyme-specific profiles	3.2.1.169
KEGG Ligand Database for Enzyme Nomenclature	3.2.1.169
IUBMB Enzyme Nomenclature	3.2.1.169
IntEnz	3.2.1.169
MEDLINE	Find literature relating to 3.2.1.169
MetaCyc	3.2.1.169
UniProtKB/Swiss-Prot	O60502, NCOAT_HUMAN;   Q9EQQ9, NCOAT_MOUSE;   Q89ZI2, OGA_BACTN;   Q0TR53, OGA_CLOP1;   Q8XL08, OGA_CLOPE;

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
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