ENZYME entry: EC 3.2.1.18

Accepted Name
Exo-alpha-sialidase.
Alternative Name(s)
Alpha-neuraminidase.
N-acylneuraminate glycohydrolase.
Neuraminidase.
Sialidase.
Reaction catalysed
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates
Comment(s)
  • The enzyme does not act on 4-O-acetylated sialic acids.
  • An endo-alpha-sialidase activity is listed as EC 3.2.1.129.
  • See also EC 4.2.2.15.
Cross-references
BRENDA3.2.1.18
EC2PDB3.2.1.18
ExplorEnz3.2.1.18
PRIAM enzyme-specific profiles3.2.1.18
KEGG Ligand Database for Enzyme Nomenclature3.2.1.18
IUBMB Enzyme Nomenclature3.2.1.18
IntEnz3.2.1.18
MEDLINEFind literature relating to 3.2.1.18
MetaCyc3.2.1.18
UniProtKB/Swiss-Prot
P18269, 8511_TRYCR;  P18270, 8512_TRYCR;  P18271, 8513_TRYCR;  
P19762, HN_MUMP1;  P11235, HN_MUMPM;  P10866, HN_MUMPR;  
P12554, HN_NDVA;  P32884, HN_NDVB;  Q91UL0, HN_NDVB1;  
P35740, HN_NDVC;  P12555, HN_NDVD;  P35741, HN_NDVH3;  
P12559, HN_NDVH4;  P12556, HN_NDVI;  P35742, HN_NDVJ;  
Q9Q2W5, HN_NDVK;  P35743, HN_NDVL;  P12557, HN_NDVM;  
P13850, HN_NDVQ;  P12553, HN_NDVTG;  P12558, HN_NDVU;  
P16071, HN_PI1HW;  P25465, HN_PI2H;  P25466, HN_PI2HT;  
P06167, HN_PI3B;  P08492, HN_PI3H4;  P12561, HN_PI3HA;  
P12562, HN_PI3HT;  P12563, HN_PI3HU;  P12564, HN_PI3HV;  
P12565, HN_PI3HW;  P12566, HN_PI3HX;  P21526, HN_PI4HA;  
Q783Y1, HN_SENDA;  P19758, HN_SENDF;  P03425, HN_SENDH;  
Q88261, HN_SENDO;  P04853, HN_SENDZ;  P25180, HN_SV41;  
P04850, HN_SV5;  P28883, HN_SV5CM;  P28884, HN_SV5CP;  
P28885, HN_SV5LN;  P62575, NANA_STREE;  P62576, NANA_STRR6;  
Q54727, NANB_STRPN;  P31206, NANH_BACFR;  P10481, NANH_CLOPF;  
P29767, NANH_CLOSE;  P15698, NANH_CLOSO;  Q02834, NANH_MICVI;  
P29768, NANH_SALTY;  A5F7A4, NANH_VIBC3;  P0C6E9, NANH_VIBCH;  
A6BMK7, NEUR1_BOVIN;  Q99519, NEUR1_HUMAN;  O35657, NEUR1_MOUSE;  
A5PF10, NEUR1_PIG;  Q5RAF4, NEUR1_PONAB;  Q99PW3, NEUR1_RAT;  
Q64393, NEUR2_CRIGR;  Q9Y3R4, NEUR2_HUMAN;  Q9JMH3, NEUR2_MOUSE;  
Q64627, NEUR2_RAT;  O97859, NEUR3_BOVIN;  Q9UQ49, NEUR3_HUMAN;  
Q9JMH7, NEUR3_MOUSE;  Q99PW5, NEUR3_RAT;  Q8WWR8, NEUR4_HUMAN;  
Q8BZL1, NEUR4_MOUSE;  P18881, NRAM_I000F;  Q8QPK2, NRAM_I00A0;  
Q289M4, NRAM_I00A1;  Q809V0, NRAM_I01A0;  Q809V4, NRAM_I01A1;  
Q809V2, NRAM_I01A2;  Q809U7, NRAM_I01A3;  Q6DPK2, NRAM_I02A1;  
Q6DPK1, NRAM_I02A2;  Q6DPK0, NRAM_I02A3;  Q6DPJ9, NRAM_I02A4;  
Q6J8D5, NRAM_I02A5;  Q6DPJ8, NRAM_I02A6;  Q6DPI6, NRAM_I02A7;  
Q6J8E4, NRAM_I03A0;  Q6DPH9, NRAM_I03A1;  Q2LFV4, NRAM_I05A1;  
B4URD9, NRAM_I06A0;  A8C8J7, NRAM_I07A0;  Q9IGQ6, NRAM_I18A0;  
P03470, NRAM_I33A0;  Q64968, NRAM_I34A0;  P03468, NRAM_I34A1;  
A4GCM2, NRAM_I35A3;  A4GCI9, NRAM_I36A0;  Q0HD57, NRAM_I40A0;  
A4GCL1, NRAM_I43A0;  A4U6V5, NRAM_I45A0;  Q8JSD9, NRAM_I47A0;  
P03480, NRAM_I49A1;  A4U7A9, NRAM_I51A0;  P31349, NRAM_I54A0;  
A4K146, NRAM_I54A2;  A3KF10, NRAM_I56A1;  Q6XV27, NRAM_I56A2;  
P88838, NRAM_I56A3;  Q1K9Q1, NRAM_I57A0;  Q67212, NRAM_I57A1;  
Q67214, NRAM_I57A2;  P03484, NRAM_I57A4;  Q6XUE4, NRAM_I57A5;  
Q710U6, NRAM_I59A0;  Q6XUD6, NRAM_I60A0;  Q6XV52, NRAM_I61A0;  
B3EUQ9, NRAM_I61A1;  Q595Z2, NRAM_I63A1;  Q07579, NRAM_I63A2;  
Q07599, NRAM_I63A3;  Q07584, NRAM_I65A0;  Q0A456, NRAM_I66A1;  
P06820, NRAM_I67A0;  A8C8W6, NRAM_I67A2;  Q75VQ4, NRAM_I68A0;  
P03477, NRAM_I68A3;  Q91MA2, NRAM_I68A4;  Q6XUA7, NRAM_I68A5;  
P03473, NRAM_I68A6;  Q6XTN2, NRAM_I69A0;  Q07581, NRAM_I69A2;  
Q6XTM7, NRAM_I70A0;  P03471, NRAM_I71A1;  P03476, NRAM_I71A2;  
Q07576, NRAM_I72A0;  Q07571, NRAM_I72A1;  P03483, NRAM_I72A2;  
P03475, NRAM_I72A3;  Q2ICQ7, NRAM_I72A4;  P03478, NRAM_I72A5;  
P06819, NRAM_I73A0;  Q1PUD6, NRAM_I73A5;  P08327, NRAM_I74A1;  
Q07573, NRAM_I74A2;  Q30NP8, NRAM_I75A0;  P03482, NRAM_I75A3;  
P03472, NRAM_I75A5;  P03479, NRAM_I76A1;  Q2RFA3, NRAM_I76A6;  
Q76WJ1, NRAM_I76A7;  Q09104, NRAM_I76A9;  Q09105, NRAM_I76AB;  
Q9IGQ0, NRAM_I76AI;  Q6XV26, NRAM_I76AK;  Q9EA42, NRAM_I77A4;  
A4GBY0, NRAM_I77AA;  P03469, NRAM_I77AB;  Q6XV23, NRAM_I77AF;  
Q6XV28, NRAM_I77AG;  Q75VQ0, NRAM_I77AH;  P03481, NRAM_I78A0;  
Q2VNF0, NRAM_I78A7;  Q2VND0, NRAM_I78A8;  Q09106, NRAM_I78AB;  
Q07585, NRAM_I78AC;  P06818, NRAM_I79A0;  P31348, NRAM_I79A4;  
Q07580, NRAM_I79A6;  Q6XV43, NRAM_I79A7;  Q2VC95, NRAM_I80A2;  
Q2RCH3, NRAM_I80A4;  Q07572, NRAM_I80A6;  Q20NP0, NRAM_I80A8;  
A4GCK0, NRAM_I80AA;  Q20NV8, NRAM_I80AD;  P08326, NRAM_I81A2;  
P26143, NRAM_I82A2;  Q67344, NRAM_I82A7;  P11485, NRAM_I83A1;  
Q0A2G2, NRAM_I83A4;  Q0A2I4, NRAM_I83A5;  P09573, NRAM_I83A6;  
P09574, NRAM_I83A7;  Q38SQ5, NRAM_I83A8;  Q07574, NRAM_I84A0;  
P05803, NRAM_I84A1;  Q6XV24, NRAM_I84A4;  Q0A2R1, NRAM_I85A3;  
Q6TXB9, NRAM_I85A5;  P31510, NRAM_I85A8;  Q07582, NRAM_I86A3;  
Q07570, NRAM_I88A1;  Q07577, NRAM_I88A4;  Q07578, NRAM_I89A7;  
Q07583, NRAM_I90A1;  Q07575, NRAM_I91A0;  O91744, NRAM_I93A0;  
Q9Q0U7, NRAM_I96A0;  O91745, NRAM_I96A1;  A3DRP3, NRAM_I96A2;  
Q07FI2, NRAM_I96A3;  Q9WAA1, NRAM_I97A0;  Q9W7Y7, NRAM_I97A1;  
P27907, NRAM_INBBE;  P16191, NRAM_INBHK;  P03474, NRAM_INBLE;  
P67923, NRAM_INBLN;  P16195, NRAM_INBMD;  P67907, NRAM_INBME;  
P16199, NRAM_INBMF;  P16201, NRAM_INBOR;  P16203, NRAM_INBSI;  
P16205, NRAM_INBUS;  P16207, NRAM_INBVI;  Q90021, NRAM_INBYB;  
P23253, TCNA_TRYCR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
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