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ENZYME

ENZYME entry: EC 3.2.1.180

PURL: https://purl.expasy.org/enzyme/EC/3.2.1.180
Accepted Name
unsaturated chondroitin disaccharide hydrolase
Alternative Name(s)
unsaturated glucuronyl hydrolase
Reaction catalysed
beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = N-acetyl-beta-D-galactosamine 6-sulfate + 5-dehydro-4-deoxy-D-glucuronate
Comment(s)
  • The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds.
  • It prefers the sulfated disaccharides to the unsulfated disaccharides.
Cross-references
BRENDA3.2.1.180
EC2PDB3.2.1.180
ExplorEnz3.2.1.180
KEGG Ligand Database for Enzyme Nomenclature3.2.1.180
IUBMB Enzyme Nomenclature3.2.1.180
MEDLINEFind literature relating to 3.2.1.180
MetaCyc3.2.1.180
Rhea expert-curated reactions3.2.1.180
UniProtKB/Swiss-Prot
Q8E372, UCDH_STRA3Q9A0T3, UCDH_STRP1Q8DR77, UCDH_STRR6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-