ID   3.2.1.183
DE   UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
AN   UDP-N-acetylglucosamine 2-epimerase.
CA   H2O + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N-acetyl-D-mannosamine +
CA   UDP.
CC   -!- The enzyme is found in mammalian liver, as well as in some pathogenic
CC       bacteria including Neisseria meningitidis and Staphylococcus aureus.
CC   -!- It catalyzes the first step of sialic acid (N-acetylneuraminic acid)
CC       biosynthesis.
CC   -!- The initial product formed is the alpha anomer, which rapidly
CC       mutarotates to a mixture of anomers.
CC   -!- The mammalian enzyme is bifunctional and also catalyzes EC 2.7.1.60.
CC       cf. EC 5.1.3.14.
DR   Q7TQ49, GLCNE_CRIGR;  Q9Y223, GLCNE_HUMAN;  Q91WG8, GLCNE_MOUSE;
DR   O35826, GLCNE_RAT  ;  H2VFI5, SIAA_NEIMB ;
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