ID   3.2.1.184
DE   UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing).
AN   UDP-Bac2Ac4Ac 2-epimerase.
CA   H2O + UDP-N,N'-diacetylbacillosamine = 2,4-diacetamido-2,4,6-trideoxy-
CA   alpha-D-mannopyranose + H(+) + UDP.
CC   -!- Involved in biosynthesis of legionaminic acid, a nonulosonate
CC       derivative that is incorporated by some bacteria into assorted
CC       virulence-associated cell surface glycoconjugates.
CC   -!- The initial product formed by the enzyme from Legionella pneumophila,
CC       which incorporates legionaminic acid into the O-antigen moiety of its
CC       lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-
CC       mannopyranose, which rapidly mutarotates to a mixture of anomers.
CC   -!- The enzyme from Campylobacter jejuni, which incorporates legionaminic
CC       acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine.
DR   Q0P8T0, NEUCH_CAMJE;  Q5ZXH8, NEUCH_LEGPH;
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