| Accepted Name |
|---|
| ipecoside beta-D-glucosidase
|
| Alternative Name(s) |
|---|
| 6-O-methyl-deacetylisoipecoside beta-glucosidase |
| IpeGlu(1) |
| Reaction catalysed |
|---|
- H2O + ipecoside = D-glucose + ipecoside aglycone
- H2O + N-deacetylipecoside = D-glucose + N-deacetylipecoside aglycone
- 6-O-methyl-N-deacetylipecoside + H2O = 6-O-methyl-N-deacetylipecoside aglycone + D-glucose
|
| Comment(s) |
|---|
- The enzyme, isolated from the roots of the plant Carapichea
ipecacuanha, preferentially hydrolyzes glucosidic ipecoside alkaloids
except for their lactams, but shows poor or no activity toward other
substrates.
- IpeGlu(1) activity is extremely poor toward 7-O-methyl and 6,7-
O,O-dimethyl derivatives. However, 6-O-methyl derivatives are
hydrolyzed as efficiently as non-methylated substrates.
- IpeGlu(1) accepts both 1alpha(S)-N-deacetylisoipecoside and 1beta(R)-
N-deacetylipecoside epimers as substrate, with preference for the
1beta(R)-epimer.
- 6-O-methyl-N-deacetylisoipecoside is an intermediate in the
biosynthesis of the medicinal alkaloid emetine.
|
| Cross-references |
|---|
| BRENDA | 3.2.1.220 |
| EC2PDB | 3.2.1.220 |
| ExplorEnz | 3.2.1.220 |
| PRIAM enzyme-specific profiles | 3.2.1.220 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.1.220 |
| IUBMB Enzyme Nomenclature | 3.2.1.220 |
| IntEnz | 3.2.1.220 |
| MEDLINE | Find literature relating to 3.2.1.220 |
| MetaCyc | 3.2.1.220 |
| Rhea expert-curated reactions | 3.2.1.220 |
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