ENZYME entry: EC 3.2.1.33

Accepted Name
Amylo-alpha-1,6-glucosidase.
Alternative Name(s)
Amylo-1,6-glucosidase.
Dextrin 6-alpha-D-glucosidase.
Reaction catalysed
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin
Comment(s)
  • This enzyme hydrolyzes an unsubstituted (1->6)-alpha-glucose residue that forms a branch point on an alpha-(1->4)-linked glucose chain.
  • The enzyme activity found in mammals and Saccharomyces cerevisiae is in a polypeptide chain containing two active centers.
  • The other activity is similar to that of EC 2.4.1.25, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyze.
  • Together, these two activities constitute the glycogen debranching system.
Cross-references
BRENDA3.2.1.33
EC2PDB3.2.1.33
ExplorEnz3.2.1.33
PRIAM enzyme-specific profiles3.2.1.33
KEGG Ligand Database for Enzyme Nomenclature3.2.1.33
IUBMB Enzyme Nomenclature3.2.1.33
IntEnz3.2.1.33
MEDLINEFind literature relating to 3.2.1.33
MetaCyc3.2.1.33
UniProtKB/Swiss-Prot
Q2PQH8, GDE_CANFA;  A8BQB4, GDE_HORSE;  P35573, GDE_HUMAN;  
P35574, GDE_RABIT;  Q06625, GDE_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-