ENZYME entry: EC 3.2.1.35

Accepted Name
Hyaluronoglucosaminidase.
Alternative Name(s)
Chondroitinase.
Chondroitinase I.
Hyaluronidase.
Hyaluronoglucosidase.
Reaction catalysed
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
Comment(s)
  • Also hydrolyzes 1,4-beta-D-glycosidic linkages between N-acetyl- galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
  • Formerly EC 3.2.1.34.
Cross-references
BRENDA3.2.1.35
EC2PDB3.2.1.35
ExplorEnz3.2.1.35
PRIAM enzyme-specific profiles3.2.1.35
KEGG Ligand Database for Enzyme Nomenclature3.2.1.35
IUBMB Enzyme Nomenclature3.2.1.35
IntEnz3.2.1.35
MEDLINEFind literature relating to 3.2.1.35
MetaCyc3.2.1.35
UniProtKB/Swiss-Prot
P50828, HEMO_PIG;  P49370, HUGAA_VESVU;  Q08169, HUGA_APIME;  
P49371, HUGA_DOLMA;  P86274, HUGA_PHOKE;  Q9U6V9, HUGA_POLAN;  
P86687, HUGA_POLPI;  P85841, HUGA_TITSE;  P0CH89, HUGA_VESMC;  
P86875, HUGA_VESMG;  Q5E985, HYAL1_BOVIN;  Q12794, HYAL1_HUMAN;  
P86100, HYAL1_MESMA;  Q91ZJ9, HYAL1_MOUSE;  Q6RHW4, HYAL1_PIG;  
Q76HN1, HYAL1_RAT;  Q8SQG8, HYAL2_BOVIN;  Q12891, HYAL2_HUMAN;  
O35632, HYAL2_MOUSE;  Q9Z2Q3, HYAL2_RAT;  Q8SQG7, HYAL2_SHEEP;  
O43820, HYAL3_HUMAN;  Q8VEI3, HYAL3_MOUSE;  Q6RHW2, HYAL3_PIG;  
Q5REQ1, HYAL3_PONAB;  Q76HM9, HYAL3_RAT;  Q2M3T9, HYAL4_HUMAN;  
Q05A56, HYAL4_MOUSE;  P23613, HYALP_CAVPO;  P38567, HYALP_HUMAN;  
P38568, HYALP_MACFA;  P48794, HYALP_MOUSE;  P38566, HYALP_RABIT;  
Q62803, HYALP_RAT;  P0C8X3, HYAL_TITST;  P15316, HYLP1_BPH44;  
Q54699, HYLP2_BPH45;  P26831, NAGH_CLOPE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-