ID   3.2.1.62
DE   glycosylceramidase.
AN   cerebrosidase.
AN   glycosyl ceramide glycosylhydrolase.
AN   glycosyl-N-acylsphingosine glycohydrolase.
AN   lactase-phlorizin hydrolase.
AN   phloretin-glucosidase.
AN   phloridzin beta-glucosidase.
AN   phloridzin glucosidase.
AN   phlorizin hydrolase.
CA   (1) glycosyl-N-acylsphingosine + H2O = N-acylsphingosine + a sugar.
CA   (2) a beta-D-galactosyl-N-acylsphingosine + H2O = a ceramide + beta-D-
CA   galactose.
CA   (3) a flavonoid-O-beta-D-glucoside + H2O = a flavonoid + beta-D-glucose.
CC   -!- The enzyme, found in the intestinal mucosa, hydrolyzes beta-D-
CC       glucosyl and beta-D-galactosyl residues from a very broad range of
CC       substrates using a retaining mechanism.
CC   -!- Characterized substrates include glucosyl- and galactosyl-ceramides,
CC       O(3)-, O(4') and O(7)-glucosylated flavonoids, and the 2'-O-
CC       glucosylated dihydrochalcone phlorizin.
CC   -!- The enzyme includes two glycosyl hydrolase domains, both belonging to
CC       the GH1 family.
CC   -!- While one domain is responsible for the activity described here,
CC       the other catalyzes the reaction of EC 3.2.1.108. cf. EC 3.2.1.45 and
CC       EC 3.2.1.46.
DR   P09848, LPH_HUMAN  ;  P09849, LPH_RABIT  ;  Q02401, LPH_RAT    ;
DR   W5PLZ6, LPH_SHEEP  ;
//