ENZYME entry: EC 3.2.2.28

Accepted Name
Double-stranded uracil-DNA glycosylase.
Alternative Name(s)
DsUDG.
Reaction catalysed
Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil
Comment(s)
  • No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N(4)-ethenocytosine residue, significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing Escherichia coli.
  • Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms.
  • Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.
Cross-references
BRENDA3.2.2.28
EC2PDB3.2.2.28
ExplorEnz3.2.2.28
PRIAM enzyme-specific profiles3.2.2.28
KEGG Ligand Database for Enzyme Nomenclature3.2.2.28
IUBMB Enzyme Nomenclature3.2.2.28
IntEnz3.2.2.28
MEDLINEFind literature relating to 3.2.2.28
MetaCyc3.2.2.28
UniProtKB/Swiss-Prot
A8APW0, MUG_CITK8;  A7MJU3, MUG_CROS8;  A7ZRV0, MUG_ECO24;  
B7MB04, MUG_ECO45;  B7LH04, MUG_ECO55;  Q8XAN4, MUG_ECO57;  
B5YRA8, MUG_ECO5E;  B7NJT2, MUG_ECO7I;  B7N0L8, MUG_ECO81;  
B7LZL8, MUG_ECO8A;  C4ZQY5, MUG_ECOBW;  B1XG73, MUG_ECODH;  
A8A4M5, MUG_ECOHS;  A1AFY9, MUG_ECOK1;  Q0TD38, MUG_ECOL5;  
P0A9H2, MUG_ECOL6;  B1IRP8, MUG_ECOLC;  P0A9H1, MUG_ECOLI;  
B7ND57, MUG_ECOLU;  B6I441, MUG_ECOSE;  B1LF61, MUG_ECOSM;  
Q1R6R1, MUG_ECOUT;  A4WEK3, MUG_ENT38;  B7LQE3, MUG_ESCF3;  
B5XU18, MUG_KLEP3;  A6TE50, MUG_KLEP7;  Q6D9D7, MUG_PECAS;  
C6DKG5, MUG_PECCP;  B5F6A8, MUG_SALA4;  A9MPV1, MUG_SALAR;  
Q57JP7, MUG_SALCH;  B5FHU7, MUG_SALDC;  B5QZ48, MUG_SALEP;  
B5REH0, MUG_SALG2;  B4TI63, MUG_SALHS;  B4T682, MUG_SALNS;  
Q5PKX5, MUG_SALPA;  A9N5Z1, MUG_SALPB;  C0PYY5, MUG_SALPC;  
B5BG24, MUG_SALPK;  B4TVU6, MUG_SALSV;  Q8XFG2, MUG_SALTI;  
Q7CPR7, MUG_SALTY;  P43343, MUG_SERMA;  A8GJV5, MUG_SERP5;  
B2U1S3, MUG_SHIB3;  Q31WW5, MUG_SHIBS;  Q32BP9, MUG_SHIDS;  
Q0T0J4, MUG_SHIF8;  Q3YXH4, MUG_SHISS;  O59825, TDG_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
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