ID 3.2.2.28 DE double-stranded uracil-DNA glycosylase. AN dsUDG. CA Specifically hydrolyzes mismatched double-stranded DNA and CA polynucleotides, releasing free uracil. CC -!- No activity on DNA containing a T/G mispair or single-stranded DNA CC containing either a site-specific uracil or 3,N(4)-ethenocytosine CC residue, significant role for double-stranded uracil-DNA glycosylase CC in mutation avoidance in non-dividing Escherichia coli. CC -!- Uracil-DNA glycosylases are widespread enzymes that are found in all CC living organisms. CC -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA CC glycosylase (EC 3.2.2.28) form a central part of the DNA-repair CC machinery since they initiate the DNA base-excision repair pathway by CC hydrolyzing the N-glycosidic bond between uracil and the deoxyribose CC sugar thereby catalyzing the removal of mis-incorporated uracil from CC DNA. DR A8APW0, MUG_CITK8 ; A7MJU3, MUG_CROS8 ; A7ZRV0, MUG_ECO24 ; DR B7MB04, MUG_ECO45 ; B7LH04, MUG_ECO55 ; Q8XAN4, MUG_ECO57 ; DR B5YRA8, MUG_ECO5E ; B7NJT2, MUG_ECO7I ; B7N0L8, MUG_ECO81 ; DR B7LZL8, MUG_ECO8A ; C4ZQY5, MUG_ECOBW ; B1XG73, MUG_ECODH ; DR A8A4M5, MUG_ECOHS ; A1AFY9, MUG_ECOK1 ; Q0TD38, MUG_ECOL5 ; DR P0A9H2, MUG_ECOL6 ; B1IRP8, MUG_ECOLC ; P0A9H1, MUG_ECOLI ; DR B7ND57, MUG_ECOLU ; B6I441, MUG_ECOSE ; B1LF61, MUG_ECOSM ; DR Q1R6R1, MUG_ECOUT ; A4WEK3, MUG_ENT38 ; B7LQE3, MUG_ESCF3 ; DR B5XU18, MUG_KLEP3 ; A6TE50, MUG_KLEP7 ; Q6D9D7, MUG_PECAS ; DR C6DKG5, MUG_PECCP ; B5F6A8, MUG_SALA4 ; A9MPV1, MUG_SALAR ; DR Q57JP7, MUG_SALCH ; B5FHU7, MUG_SALDC ; B5QZ48, MUG_SALEP ; DR B5REH0, MUG_SALG2 ; B4TI63, MUG_SALHS ; B4T682, MUG_SALNS ; DR Q5PKX5, MUG_SALPA ; A9N5Z1, MUG_SALPB ; C0PYY5, MUG_SALPC ; DR B5BG24, MUG_SALPK ; B4TVU6, MUG_SALSV ; Q8XFG2, MUG_SALTI ; DR Q7CPR7, MUG_SALTY ; P43343, MUG_SERMA ; A8GJV5, MUG_SERP5 ; DR B2U1S3, MUG_SHIB3 ; Q31WW5, MUG_SHIBS ; Q32BP9, MUG_SHIDS ; DR Q0T0J4, MUG_SHIF8 ; Q3YXH4, MUG_SHISS ; O59825, TDG_SCHPO ; //