ENZYME entry: EC 3.3.1.1

Accepted Name
Adenosylhomocysteinase.
Alternative Name(s)
Adenosylhomocysteine hydrolase.
AdoHcyase.
S-adenosylhomocysteinase.
S-adenosylhomocysteine hydrolase.
S-adenosylhomocysteine synthase.
SAHase.
Reaction catalysed
S-adenosyl-L-homocysteine + H(2)O <=> L-homocysteine + adenosine
Cofactor(s)
NAD(+).
Comment(s)
The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.
Cross-references
PROSITEPDOC00603
BRENDA3.3.1.1
EC2PDB3.3.1.1
ExplorEnz3.3.1.1
PRIAM enzyme-specific profiles3.3.1.1
KEGG Ligand Database for Enzyme Nomenclature3.3.1.1
IUBMB Enzyme Nomenclature3.3.1.1
IntEnz3.3.1.1
MEDLINEFind literature relating to 3.3.1.1
MetaCyc3.3.1.1
UniProtKB/Swiss-Prot
O23255, SAHH1_ARATH;  P84533, SAHH1_POPEU;  Q9LK36, SAHH2_ARATH;  
P50245, SAHH2_DROME;  O43865, SAHH2_HUMAN;  Q80SW1, SAHH2_MOUSE;  
P84532, SAHH2_POPEU;  B5DFN2, SAHH2_RAT;  A6QLP2, SAHH3_BOVIN;  
Q96HN2, SAHH3_HUMAN;  Q68FL4, SAHH3_MOUSE;  Q5R889, SAHH3_PONAB;  
P51893, SAHHA_XENLA;  O93477, SAHHB_XENLA;  A1TUG3, SAHH_ACIAC;  
Q6FA43, SAHH_ACIAD;  B9MD45, SAHH_ACIET;  A1W3P0, SAHH_ACISJ;  
Q9YEF2, SAHH_AERPE;  Q8UJ99, SAHH_AGRFC;  B9JG53, SAHH_AGRRK;  
O76757, SAHH_ANOGA;  O67240, SAHH_AQUAE;  O28279, SAHH_ARCFU;  
Q5P6B7, SAHH_AROAE;  Q64MT2, SAHH_BACFR;  Q8A407, SAHH_BACTN;  
Q6G584, SAHH_BARHE;  Q6G1D6, SAHH_BARQU;  A9IL83, SAHH_BART1;  
Q6MNC0, SAHH_BDEBA;  Q7WQX5, SAHH_BORBR;  Q7W1Z7, SAHH_BORPA;  
A9IGY5, SAHH_BORPD;  Q7VUL8, SAHH_BORPE;  Q3MHL4, SAHH_BOVIN;  
Q89HP6, SAHH_BRADU;  A5ENA7, SAHH_BRASB;  B2S994, SAHH_BRUA1;  
Q2YQX8, SAHH_BRUA2;  Q57AG3, SAHH_BRUAB;  A9M9T1, SAHH_BRUC2;  
C0RFY3, SAHH_BRUMB;  Q8YE49, SAHH_BRUME;  A5VT52, SAHH_BRUO2;  
B0CJJ7, SAHH_BRUSI;  Q8FXZ7, SAHH_BRUSU;  A3MQW7, SAHH_BURM7;  
A2S6W2, SAHH_BURM9;  Q62G22, SAHH_BURMA;  A1V8Z2, SAHH_BURMS;  
A3P0L8, SAHH_BURP0;  Q3JY79, SAHH_BURP1;  A3NER1, SAHH_BURP6;  
Q63PT2, SAHH_BURPS;  Q2STU0, SAHH_BURTA;  Q13T36, SAHH_BURXL;  
P27604, SAHH_CAEEL;  P83783, SAHH_CANAL;  P35007, SAHH_CATRO;  
Q9ABH0, SAHH_CAUCR;  Q11CD0, SAHH_CHESB;  Q3AQC2, SAHH_CHLCH;  
B3EDY3, SAHH_CHLL2;  Q3B532, SAHH_CHLL7;  B3QMF5, SAHH_CHLP8;  
A1BEZ2, SAHH_CHLPD;  A4SF77, SAHH_CHLPM;  Q8KEG8, SAHH_CHLTE;  
Q7NZF7, SAHH_CHRVO;  P61456, SAHH_CORDI;  Q8FRJ4, SAHH_COREF;  
A4QC87, SAHH_CORGB;  Q8NSC4, SAHH_CORGL;  B6J6H1, SAHH_COXB1;  
B6J3R0, SAHH_COXB2;  A9KD88, SAHH_COXBN;  Q83A77, SAHH_COXBU;  
Q1LS20, SAHH_CUPMC;  Q0KF25, SAHH_CUPNH;  Q476T8, SAHH_CUPPJ;  
B2AGG2, SAHH_CUPTR;  B7K8X6, SAHH_CYAP7;  A9C184, SAHH_DELAS;  
C6C1F4, SAHH_DESAD;  Q30WL8, SAHH_DESAG;  Q72EH1, SAHH_DESVH;  
B8DR41, SAHH_DESVM;  A1VFZ7, SAHH_DESVV;  P10819, SAHH_DICDI;  
Q27580, SAHH_DROME;  A5FJK3, SAHH_FLAJ1;  A6GW32, SAHH_FLAPJ;  
P61617, SAHH_GEOSL;  Q7NGI6, SAHH_GLOVI;  Q0BW40, SAHH_GRABC;  
A0M5W6, SAHH_GRAFK;  Q2SLT4, SAHH_HAHCH;  A1WXM7, SAHH_HALHL;  
B0R7F2, SAHH_HALS3;  Q9HN50, SAHH_HALSA;  G0LFB0, SAHH_HALWC;  
Q18EV6, SAHH_HALWD;  A4G975, SAHH_HERAR;  P23526, SAHH_HUMAN;  
Q0C427, SAHH_HYPNA;  A6T2Y9, SAHH_JANMA;  P36889, SAHH_LEIDO;  
Q04NN6, SAHH_LEPBJ;  Q04WX0, SAHH_LEPBL;  B1Y647, SAHH_LEPCP;  
Q75FU8, SAHH_LEPIC;  Q8EXV1, SAHH_LEPIN;  Q9SP37, SAHH_LUPLU;  
Q4R596, SAHH_MACFA;  Q0ALW1, SAHH_MARMM;  P50246, SAHH_MEDSA;  
P93253, SAHH_MESCR;  Q8TRA5, SAHH_METAC;  B7KSJ4, SAHH_METC4;  
Q60CG8, SAHH_METCA;  A9VYP7, SAHH_METEP;  Q58783, SAHH_METJA;  
P58855, SAHH_METKA;  Q8PUQ4, SAHH_METMA;  Q6LYR8, SAHH_METMP;  
B8IPU4, SAHH_METNO;  B1ZLX0, SAHH_METPB;  A2SL00, SAHH_METPP;  
B0UM37, SAHH_METS4;  O27673, SAHH_METTH;  P50247, SAHH_MOUSE;  
Q7TWW7, SAHH_MYCBO;  A1KNQ0, SAHH_MYCBP;  C1AH22, SAHH_MYCBT;  
B8ZQE9, SAHH_MYCLB;  Q9CCJ4, SAHH_MYCLE;  B2HEP6, SAHH_MYCMM;  
Q73UK6, SAHH_MYCPA;  A4ZHR8, SAHH_MYCS2;  A3PW97, SAHH_MYCSJ;  
A1UCK8, SAHH_MYCSK;  Q1BCD6, SAHH_MYCSS;  A5U7S2, SAHH_MYCTA;  
P9WGV2, SAHH_MYCTO;  P9WGV3, SAHH_MYCTU;  A0PRF5, SAHH_MYCUA;  
Q1CY84, SAHH_MYXXD;  P68172, SAHH_NICSY;  Q0AEV8, SAHH_NITEC;  
Q82WL1, SAHH_NITEU;  Q5YQS7, SAHH_NOCFA;  Q8YX05, SAHH_NOSS1;  
Q2G6T1, SAHH_NOVAD;  A6WX40, SAHH_OCHA4;  B2JIP4, SAHH_PARP8;  
B2T6X2, SAHH_PARPJ;  Q3A392, SAHH_PELCD;  B4SD43, SAHH_PELPB;  
Q01781, SAHH_PETCR;  P50249, SAHH_PHASS;  Q710C4, SAHH_PIG;  
Q4XZZ5, SAHH_PLACH;  P50250, SAHH_PLAF7;  Q7RKK8, SAHH_PLAYO;  
Q12663, SAHH_PNECA;  B1XSH8, SAHH_POLNS;  A4T0E9, SAHH_POLSQ;  
A3PFB5, SAHH_PROM0;  A8G7D1, SAHH_PROM2;  A2C620, SAHH_PROM3;  
A9BD69, SAHH_PROM4;  Q318B6, SAHH_PROM9;  Q7V9P3, SAHH_PROMA;  
Q7V926, SAHH_PROMM;  Q7UZN3, SAHH_PROMP;  Q48PB5, SAHH_PSE14;  
B7V419, SAHH_PSEA8;  Q02TY0, SAHH_PSEAB;  Q9I685, SAHH_PSEAE;  
Q1I3W5, SAHH_PSEE4;  Q4K4H7, SAHH_PSEF5;  C3K3G6, SAHH_PSEFS;  
A4XPF3, SAHH_PSEMY;  A5WA09, SAHH_PSEP1;  Q3K5D7, SAHH_PSEPF;  
B0KM00, SAHH_PSEPG;  B1J2Y8, SAHH_PSEPW;  Q87V73, SAHH_PSESM;  
Q4ZZ92, SAHH_PSEU2;  A4VRF7, SAHH_PSEU5;  Q9UYK5, SAHH_PYRAB;  
Q8ZTQ7, SAHH_PYRAE;  P50251, SAHH_PYRFU;  O58275, SAHH_PYRHO;  
B2U774, SAHH_RALPJ;  Q8Y387, SAHH_RALSO;  P10760, SAHH_RAT;  
B3PVW2, SAHH_RHIE6;  Q2KE72, SAHH_RHIEC;  Q1MNC6, SAHH_RHIL3;  
Q98CM3, SAHH_RHILO;  B5ZV80, SAHH_RHILW;  Q92TC1, SAHH_RHIME;  
Q7TTZ5, SAHH_RHOBA;  P28183, SAHH_RHOCB;  Q2IZR1, SAHH_RHOP2;  
Q6N2N5, SAHH_RHOPA;  Q13AQ5, SAHH_RHOPS;  B3QJT3, SAHH_RHOPT;  
O50562, SAHH_RHOSH;  Q9ZNA5, SAHH_ROSDO;  O13639, SAHH_SCHPO;  
A6UEJ1, SAHH_SINMW;  Q9SWF5, SAHH_SOLLC;  Q01VU1, SAHH_SOLUE;  
Q1GWT5, SAHH_SPHAL;  Q936D6, SAHH_STRAA;  Q82DC9, SAHH_STRAW;  
Q8GGL7, SAHH_STRAZ;  Q9KZM1, SAHH_STRCO;  P26799, SAHH_STRFR;  
B1VUW6, SAHH_STRGG;  Q4JAZ7, SAHH_SULAC;  P50252, SAHH_SULSO;  
Q975T0, SAHH_SULTO;  A5GI30, SAHH_SYNPW;  Q7U9Y3, SAHH_SYNPX;  
Q0IDX7, SAHH_SYNS3;  Q3B0K7, SAHH_SYNS9;  Q3ANF4, SAHH_SYNSC;  
P74008, SAHH_SYNY3;  Q9HKX4, SAHH_THEAC;  Q8DGC8, SAHH_THEEB;  
Q5JED2, SAHH_THEKO;  O51933, SAHH_THEMA;  Q979Z4, SAHH_THEVO;  
P68173, SAHH_TOBAC;  P51540, SAHH_TRIVA;  C5CM29, SAHH_VARPS;  
P32112, SAHH_WHEAT;  Q8PP84, SAHH_XANAC;  Q3BXC6, SAHH_XANC5;  
Q4UQZ8, SAHH_XANC8;  Q8PCH5, SAHH_XANCP;  Q2NZE3, SAHH_XANOM;  
B2SPN6, SAHH_XANOP;  B2I7N4, SAHH_XYLF2;  Q9PEJ1, SAHH_XYLFA;  
B0U232, SAHH_XYLFM;  Q87EI8, SAHH_XYLFT;  P39954, SAHH_YEAST;  
Q5NR48, SAHH_ZYMMO;  

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