ENZYME entry: EC 3.3.2.10

Accepted Name
Soluble epoxide hydrolase.
Alternative Name(s)
Arene-oxide hydratase.
Aryl epoxide hydrase.
Cytosolic epoxide hydrolase.
Epoxide hydrase.
Epoxide hydratase.
Trans-stilbene oxide hydrolase.
Reaction catalysed
An epoxide + H(2)O <=> a glycol
Comment(s)
  • Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.
  • It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
  • The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76.
  • Like EC 3.3.2.9, it is probable that the reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
  • The enzyme can also use leukotriene A(4), the substrate of EC 3.3.2.6, but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than leukotriene B(4) as the product.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
Cross-references
BRENDA3.3.2.10
EC2PDB3.3.2.10
ExplorEnz3.3.2.10
PRIAM enzyme-specific profiles3.3.2.10
KEGG Ligand Database for Enzyme Nomenclature3.3.2.10
IUBMB Enzyme Nomenclature3.3.2.10
IntEnz3.3.2.10
MEDLINEFind literature relating to 3.3.2.10
MetaCyc3.3.2.10
UniProtKB/Swiss-Prot
O33283, EPHG_MYCTU;  P80048, HYEP_PSEU1;  Q06816, HYEP_STIAD;  
O52866, HYES_CORS2;  P34913, HYES_HUMAN;  P34914, HYES_MOUSE;  
Q6Q2C2, HYES_PIG;  P80299, HYES_RAT;  

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