ENZYME

ENZYME entry: EC 3.3.2.10

Accepted Name

Soluble epoxide hydrolase.

Alternative Name(s)

Arene-oxide hydratase.

Aryl epoxide hydrase.

Cytosolic epoxide hydrolase.

Epoxide hydrase.

Epoxide hydratase.

Trans-stilbene oxide hydrolase.

Reaction catalysed

An epoxide + H(2)O <=> a glycol

Comment(s)

Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.
It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76.
Like EC 3.3.2.9, it is probable that the reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
The enzyme can also use leukotriene A(4), the substrate of EC 3.3.2.6, but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than leukotriene B(4) as the product.
Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature