ID 3.3.2.10 DE soluble epoxide hydrolase. AN arene-oxide hydratase. AN aryl epoxide hydrase. AN cytosolic epoxide hydrolase. AN epoxide hydrase. AN epoxide hydratase. AN trans-stilbene oxide hydrolase. CA an epoxide + H2O = an ethanediol. CC -!- Catalyzes the hydrolysis of trans-substituted epoxides, such as CC trans-stilbene oxide, as well as various aliphatic epoxides derived CC from fatty-acid metabolism. CC -!- It is involved in the metabolism of arachidonic epoxides CC (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides. CC -!- The enzyme from mammals is a bifunctional enzyme: the C-terminal CC domain exhibits epoxide-hydrolase activity and the N-terminal domain CC has the activity of EC 3.1.3.76. CC -!- Like EC 3.3.2.9, it is probable that the reaction involves the CC formation of an hydroxyalkyl-enzyme intermediate. CC -!- The enzyme can also use leukotriene A4, the substrate of EC 3.3.2.6, CC but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather CC than leukotriene B4 as the product. CC -!- Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64. DR G5EBI4, CEEH1_CAEEL; G5EDL5, CEEH2_CAEEL; I6YGS0, EPHA_MYCTU ; DR P95276, EPHB_MYCTO ; I6YC03, EPHB_MYCTU ; O33283, EPHG_MYCTU ; DR O53388, EPHH_MYCTU ; Q9H6B9, EPHX3_HUMAN; Q3V1F8, EPHX3_MOUSE; DR Q0IIS3, EPHX3_XENTR; P80048, HYEP_PSEU1 ; Q06816, HYEP_STIAD ; DR O52866, HYES_CORS2 ; P34913, HYES_HUMAN ; P34914, HYES_MOUSE ; DR Q6Q2C2, HYES_PIG ; P80299, HYES_RAT ; A5DME6, LKA41_PICGU; DR A3LRX6, LKA41_PICST; A5DGF3, LKA42_PICGU; A3LQI7, LKA42_PICST; DR A6RCT2, LKHA4_AJECN; Q9FY49, LKHA4_ARATH; A1CSI2, LKHA4_ASPCL; DR Q4X265, LKHA4_ASPFU; A2QKF8, LKHA4_ASPNC; Q2TZ99, LKHA4_ASPOR; DR Q0CFY9, LKHA4_ASPTN; Q59NB8, LKHA4_CANAL; Q6FTM0, LKHA4_CANGA; DR Q2GY21, LKHA4_CHAGB; Q1DVD1, LKHA4_COCIM; Q6BW21, LKHA4_DEBHA; DR P52922, LKHA4_DICDI; Q5B0W8, LKHA4_EMENI; Q75B10, LKHA4_EREGS; DR Q6CLD3, LKHA4_KLULA; A5DSS4, LKHA4_LODEL; A1DG68, LKHA4_NEOFI; DR Q7S785, LKHA4_NEUCR; Q84TA3, LKHA4_ORYSJ; Q0U653, LKHA4_PHANO; DR A4QUC1, LKHA4_PYRO7; O94544, LKHA4_SCHPO; A7EJL9, LKHA4_SCLS1; DR A7THG7, LKHA4_VANPO; Q6C3E5, LKHA4_YARLI; A6ZS33, LKHA4_YEAS7; DR Q10740, LKHA4_YEAST; //