ENZYME entry: EC 3.3.2.11

Accepted Name
Cholesterol-5,6-oxide hydrolase.
Alternative Name(s)
ChEH.
Cholesterol-epoxide hydrolase.
Reaction catalysed
  • 5,6-alpha-epoxy-5-alpha-cholestan-3-beta-ol + H(2)O <=> cholestane-3-beta,5-alpha,6-beta-triol
  • 5,6-beta-epoxy-5-beta-cholestan-3-beta-ol + H(2)O <=> cholestane-3-beta,5-alpha,6-beta-triol
Comment(s)
  • The enzyme appears to work equally well with both diastereoisomers of cholesterol 5,6-epoxide.
  • The product is a competitive inhibitor of the reaction.
Cross-references
BRENDA3.3.2.11
EC2PDB3.3.2.11
ExplorEnz3.3.2.11
PRIAM enzyme-specific profiles3.3.2.11
KEGG Ligand Database for Enzyme Nomenclature3.3.2.11
IUBMB Enzyme Nomenclature3.3.2.11
IntEnz3.3.2.11
MEDLINEFind literature relating to 3.3.2.11
MetaCyc3.3.2.11
UniProtKB/Swiss-Prot
O33283, EPHG_MYCTU

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