ID   3.3.2.6
DE   Leukotriene-A(4) hydrolase.
AN   Leukotriene A(4) hydrolase.
AN   Leukotriene-A4 hydrolase.
AN   LTA-4 hydrolase.
CA   (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O =
CA   (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.
CF   Zinc.
CC   -!- A bifunctional zinc metalloprotease that displays both epoxide
CC       hydrolase and aminopeptidase activities.
CC   -!- It preferentially cleaves tripeptides at an arginyl bond, with
CC       dipeptides and tetrapeptides being poorer substrates.
CC   -!- It also converts leukotriene A(4) into leukotriene B(4), unlike
CC       EC 3.2.2.10 which converts leukotriene A(4) into 5,6-dihydroxy-
CC       7,9,11,14-eicosatetraenoic acid.
PR   PROSITE; PDOC00129;
DR   A5DME6, LKA41_PICGU;  A3LRX6, LKA41_PICST;  A5DGF3, LKA42_PICGU;
DR   A3LQI7, LKA42_PICST;  A6RCT2, LKHA4_AJECN;  Q75B10, LKHA4_ASHGO;
DR   A1CSI2, LKHA4_ASPCL;  Q4X265, LKHA4_ASPFU;  A2QKF8, LKHA4_ASPNC;
DR   Q2TZ99, LKHA4_ASPOR;  Q0CFY9, LKHA4_ASPTN;  A6SAG8, LKHA4_BOTFB;
DR   Q3SZH7, LKHA4_BOVIN;  Q59NB8, LKHA4_CANAL;  Q6FTM0, LKHA4_CANGA;
DR   P19602, LKHA4_CAVPO;  Q2GY21, LKHA4_CHAGB;  Q6S9C8, LKHA4_CHILA;
DR   Q1DVD1, LKHA4_COCIM;  Q6BW21, LKHA4_DEBHA;  P52922, LKHA4_DICDI;
DR   Q5B0W8, LKHA4_EMENI;  P09960, LKHA4_HUMAN;  Q6CLD3, LKHA4_KLULA;
DR   A5DSS4, LKHA4_LODEL;  A4QUC1, LKHA4_MAGO7;  P24527, LKHA4_MOUSE;
DR   A1DG68, LKHA4_NEOFI;  Q7S785, LKHA4_NEUCR;  Q0U653, LKHA4_PHANO;
DR   P30349, LKHA4_RAT  ;  O94544, LKHA4_SCHPO;  A7EJL9, LKHA4_SCLS1;
DR   A7THG7, LKHA4_VANPO;  Q6C3E5, LKHA4_YARLI;  A6ZS33, LKHA4_YEAS7;
DR   Q10740, LKHA4_YEAST;
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