ENZYME entry: EC 3.3.2.9
| Accepted Name |
|---|
| Microsomal epoxide hydrolase.
|
| Alternative Name(s) |
|---|
| Arene-oxide hydratase. |
| Aryl epoxide hydrase. |
| Benzo[a]pyrene-4,5-oxide hydratase. |
| Cis-epoxide hydrolase. |
| Epoxide hydrase. |
| Epoxide hydratase. |
| MEH. |
| Microsomal epoxide hydrase. |
| Microsomal epoxide hydratase. |
| Reaction catalysed |
|---|
| Cis-stilbene oxide + H(2)O <=> (+)-(1R,2R)-1,2-diphenylethane-1,2-diol |
| Comment(s) |
|---|
- Involved in the metabolism of numerous xenobiotics, such as 1,3-
butadiene oxide, styrene oxide and the polycyclic aromatic
hydrocarbon benzo[a]pyrene 4,5-oxide.
- In a series of oxiranes with a lipophilic substituent of sufficient
size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2-
disubstituted oxiranes serve as substrates or inhibitors of the
enzyme, while trans-1,2-disubstituted, tri- and tetra-substituted
oxiranes are not substrates.
- The reaction involves the formation of an hydroxyalkyl-enzyme
intermediate.
- Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
|
| Cross-references |
|---|
| BRENDA | 3.3.2.9 |
| EC2PDB | 3.3.2.9 |
| ExplorEnz | 3.3.2.9 |
| PRIAM enzyme-specific profiles | 3.3.2.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.3.2.9 |
| IUBMB Enzyme Nomenclature | 3.3.2.9 |
| IntEnz | 3.3.2.9 |
| MEDLINE | Find literature relating to 3.3.2.9 |
| MetaCyc | 3.3.2.9 |
| UniProtKB/Swiss-Prot |
|
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