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ENZYME entry: EC 220.127.116.11
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|Microsomal epoxide hydrolase.
|Aryl epoxide hydrase.|
|Microsomal epoxide hydrase.|
|Microsomal epoxide hydratase.|
|Cis-stilbene oxide + H(2)O <=> (+)-(1R,2R)-1,2-diphenylethane-1,2-diol|
- Involved in the metabolism of numerous xenobiotics, such as 1,3-
butadiene oxide, styrene oxide and the polycyclic aromatic
hydrocarbon benzo[a]pyrene 4,5-oxide.
- In a series of oxiranes with a lipophilic substituent of sufficient
size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2-
disubstituted oxiranes serve as substrates or inhibitors of the
enzyme, while trans-1,2-disubstituted, tri- and tetra-substituted
oxiranes are not substrates.
- The reaction involves the formation of an hydroxyalkyl-enzyme
- Formerly EC 18.104.22.168, EC 22.214.171.124 and EC 126.96.36.199.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
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entries corresponding to 3.3.2.-
entries corresponding to 3.3.-.-
entries corresponding to 3.-.-.-