ENZYME entry: EC 3.3.2.9

Accepted Name
Microsomal epoxide hydrolase.
Alternative Name(s)
Arene-oxide hydratase.
Aryl epoxide hydrase.
Benzo[a]pyrene-4,5-oxide hydratase.
Cis-epoxide hydrolase.
Epoxide hydrase.
Epoxide hydratase.
MEH.
Microsomal epoxide hydrase.
Microsomal epoxide hydratase.
Reaction catalysed
Cis-stilbene oxide + H(2)O <=> (+)-(1R,2R)-1,2-diphenylethane-1,2-diol
Comment(s)
  • Involved in the metabolism of numerous xenobiotics, such as 1,3- butadiene oxide, styrene oxide and the polycyclic aromatic hydrocarbon benzo[a]pyrene 4,5-oxide.
  • In a series of oxiranes with a lipophilic substituent of sufficient size (styrene oxides), monosubstituted as well as 1,1- and cis-1,2- disubstituted oxiranes serve as substrates or inhibitors of the enzyme, while trans-1,2-disubstituted, tri- and tetra-substituted oxiranes are not substrates.
  • The reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
Cross-references
BRENDA3.3.2.9
EC2PDB3.3.2.9
ExplorEnz3.3.2.9
PRIAM enzyme-specific profiles3.3.2.9
KEGG Ligand Database for Enzyme Nomenclature3.3.2.9
IUBMB Enzyme Nomenclature3.3.2.9
IntEnz3.3.2.9
MEDLINEFind literature relating to 3.3.2.9
MetaCyc3.3.2.9
UniProtKB/Swiss-Prot
Q8MZR6, HYEP1_CTEFE;  Q8MZR5, HYEP2_CTEFE;  Q6U6J0, HYEP_BOMMO;  
P07099, HYEP_HUMAN;  Q25489, HYEP_MANSE;  Q9D379, HYEP_MOUSE;  
P79381, HYEP_PIG;  P04068, HYEP_RABIT;  P07687, HYEP_RAT;  

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