ID   3.3.2.9
DE   microsomal epoxide hydrolase.
AN   arene-oxide hydratase.
AN   aryl epoxide hydrase.
AN   benzo[a]pyrene-4,5-oxide hydratase.
AN   cis-epoxide hydrolase.
AN   epoxide hydrase.
AN   epoxide hydratase.
AN   mEH.
AN   microsomal epoxide hydrase.
AN   microsomal epoxide hydratase.
AN   microsomal oxirane/oxetane hydrolase.
CA   (1) cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin.
CA   (2) 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-
CA   yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-
CA   2-methylpropane-1,3-diol.
CC   -!- This is a key hepatic enzyme that catalyzes the hydrolytic ring
CC       opening of oxiranes (epoxides) and oxetanes to give the corresponding
CC       diols.
CC   -!- The enzyme is involved in the metabolism of numerous substrates
CC       including the stereoselective hydrolytic ring opening of
CC       7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the
CC       corresponding trans-dihydrodiols.
CC   -!- The reaction proceeds via a triad mechanism and involves the
CC       formation of an hydroxyalkyl-enzyme intermediate.
CC   -!- Five epoxide-hydrolase enzymes have been identified in vertebrates to
CC       date: EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9, EC 3.3.2.10 and
CC       EC 3.3.2.11.
CC   -!- Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
DR   Q8MZR6, HYEP1_CTEFE;  Q8MZR5, HYEP2_CTEFE;  Q6U6J0, HYEP_BOMMO ;
DR   P07099, HYEP_HUMAN ;  Q25489, HYEP_MANSE ;  Q9D379, HYEP_MOUSE ;
DR   P79381, HYEP_PIG   ;  P04068, HYEP_RABIT ;  P07687, HYEP_RAT   ;
//