ENZYME entry: EC 3.4.11.26

Accepted Name
Intermediate cleaving peptidase 55.
Reaction catalysed
The enzyme cleaves the Pro(36)-Pro(37) bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase
Comment(s)
  • Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilization of the substrate.
  • The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.
Cross-references
BRENDA3.4.11.26
EC2PDB3.4.11.26
ExplorEnz3.4.11.26
PRIAM enzyme-specific profiles3.4.11.26
KEGG Ligand Database for Enzyme Nomenclature3.4.11.26
IUBMB Enzyme Nomenclature3.4.11.26
IntEnz3.4.11.26
MEDLINEFind literature relating to 3.4.11.26
MetaCyc3.4.11.26
UniProtKB/Swiss-Prot
Q10439, ICP55_SCHPO;  P40051, ICP55_YEAST;  

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