ENZYME

ENZYME entry: EC 3.4.11.26

Accepted Name

Intermediate cleaving peptidase 55.

Reaction catalysed

The enzyme cleaves the Pro(36)-Pro(37) bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase

Comment(s)

Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilization of the substrate.
The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.

Cross-references

BRENDA

3.4.11.26

EC2PDB

3.4.11.26

ExplorEnz

3.4.11.26

PRIAM enzyme-specific profiles

3.4.11.26

KEGG Ligand Database for Enzyme Nomenclature

3.4.11.26

IUBMB Enzyme Nomenclature