ENZYME entry: EC 3.4.11.9

Accepted Name
Xaa-Pro aminopeptidase.
Alternative Name(s)
Aminoacylproline aminopeptidase.
Aminopeptidase P.
Proline aminopeptidase.
X-Pro aminopeptidase.
Reaction catalysed
Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide
Cofactor(s)
Cobalt cation or Mn(2+).
Comment(s)
  • Generally membrane bound enzyme present in both mammalian and bacterial cells.
  • Belongs to peptidase family M24B.
Cross-references
PROSITEPDOC00417
BRENDA3.4.11.9
EC2PDB3.4.11.9
ExplorEnz3.4.11.9
PRIAM enzyme-specific profiles3.4.11.9
KEGG Ligand Database for Enzyme Nomenclature3.4.11.9
IUBMB Enzyme Nomenclature3.4.11.9
IntEnz3.4.11.9
MEDLINEFind literature relating to 3.4.11.9
MetaCyc3.4.11.9
UniProtKB/Swiss-Prot
C0NDZ7, AMPP1_AJECG;  C6HSY3, AMPP1_AJECH;  A6R035, AMPP1_AJECN;  
C5GXZ9, AMPP1_AJEDR;  C5K105, AMPP1_AJEDS;  D4ARJ9, AMPP1_ARTBC;  
E4USI8, AMPP1_ARTGP;  C5FHR9, AMPP1_ARTOC;  A1CAQ1, AMPP1_ASPCL;  
B0Y3V7, AMPP1_ASPFC;  B8NEI6, AMPP1_ASPFN;  Q4WUD3, AMPP1_ASPFU;  
A2QGR5, AMPP1_ASPNC;  Q2U7S5, AMPP1_ASPOR;  Q0CDB3, AMPP1_ASPTN;  
A6RK67, AMPP1_BOTFB;  Q2H8T2, AMPP1_CHAGB;  C5P7J2, AMPP1_COCP7;  
E9CTR7, AMPP1_COCPS;  E3QCU0, AMPP1_COLGM;  A8P5H7, AMPP1_COPC7;  
Q5AVF0, AMPP1_EMENI;  B0DZL3, AMPP1_LACBS;  E5ABQ8, AMPP1_LEPMJ;  
A4RF35, AMPP1_MAGO7;  E9E9B2, AMPP1_METAQ;  E9EUE6, AMPP1_METAR;  
C7Z9Z7, AMPP1_NECH7;  A1DF27, AMPP1_NEOFI;  Q7RYL6, AMPP1_NEUCR;  
C1H978, AMPP1_PARBA;  C1GEY4, AMPP1_PARBD;  C0SCV1, AMPP1_PARBP;  
B6HQC9, AMPP1_PENCW;  B6QG01, AMPP1_PENMQ;  Q0UFY4, AMPP1_PHANO;  
B2AWV6, AMPP1_PODAN;  B2VUU7, AMPP1_PYRTR;  E3S7K9, AMPP1_PYRTT;  
A7E4T8, AMPP1_SCLS1;  D1ZKF3, AMPP1_SORMK;  P0A3Z1, AMPP1_STRCO;  
P0A3Z2, AMPP1_STRLI;  B8M9W2, AMPP1_TALSN;  D4D891, AMPP1_TRIVH;  
D5GAC6, AMPP1_TUBMM;  C9SR45, AMPP1_VERA1;  C0NF18, AMPP2_AJECG;  
C6HNY5, AMPP2_AJECH;  A6QYF6, AMPP2_AJECN;  C5GKT2, AMPP2_AJEDR;  
C5K0R2, AMPP2_AJEDS;  D4B0B2, AMPP2_ARTBC;  E4V1Q7, AMPP2_ARTGP;  
C5FUV0, AMPP2_ARTOC;  A1CNW6, AMPP2_ASPCL;  B0XN37, AMPP2_ASPFC;  
B8MZI5, AMPP2_ASPFN;  Q4WRV9, AMPP2_ASPFU;  A2QAW7, AMPP2_ASPNC;  
Q2UQH9, AMPP2_ASPOR;  Q0CZM6, AMPP2_ASPTN;  A6SL16, AMPP2_BOTFB;  
Q2HA12, AMPP2_CHAGB;  C5PAH2, AMPP2_COCP7;  E9CY14, AMPP2_COCPS;  
E3Q897, AMPP2_COLGM;  Q5BF48, AMPP2_EMENI;  A4RQ11, AMPP2_MAGO7;  
E9E2J4, AMPP2_METAQ;  E9F9J8, AMPP2_METAR;  C7Z837, AMPP2_NECH7;  
A1D1S6, AMPP2_NEOFI;  A7UWH7, AMPP2_NEUCR;  C1H3X3, AMPP2_PARBA;  
C1GHS9, AMPP2_PARBD;  C0SDW6, AMPP2_PARBP;  B6HAN0, AMPP2_PENCW;  
B6QAW7, AMPP2_PENMQ;  Q0V147, AMPP2_PHANO;  B2AW39, AMPP2_PODAN;  
B2WKR4, AMPP2_PYRTR;  E3RNJ5, AMPP2_PYRTT;  A7ENP9, AMPP2_SCLS1;  
D1ZQL9, AMPP2_SORMK;  P0A3Z3, AMPP2_STRCO;  P0A3Z4, AMPP2_STRLI;  
B8M2W9, AMPP2_TALSN;  D4D6B8, AMPP2_TRIVH;  D5GHP2, AMPP2_TUBMM;  
C4JY72, AMPP2_UNCRE;  C9SDK8, AMPP2_VERA1;  C0NIF0, AMPP3_AJECG;  
C6H7R7, AMPP3_AJECH;  C5G874, AMPP3_AJEDR;  C5JQ04, AMPP3_AJEDS;  
A1CSI0, AMPP3_ASPCL;  B0XW47, AMPP3_ASPFC;  B8NC10, AMPP3_ASPFN;  
Q4X267, AMPP3_ASPFU;  A2QKF6, AMPP3_ASPNC;  Q0CFZ0, AMPP3_ASPTN;  
A6SDE9, AMPP3_BOTFB;  C5PHM7, AMPP3_COCP7;  E9DDK8, AMPP3_COCPS;  
E3QYP0, AMPP3_COLGM;  Q96WX8, AMPP3_EMENI;  E4ZHV7, AMPP3_LEPMJ;  
A4RAE9, AMPP3_MAGO7;  E9DV56, AMPP3_METAQ;  E9EK74, AMPP3_METAR;  
C7YVN8, AMPP3_NECH7;  A1DG66, AMPP3_NEOFI;  C1H9Q9, AMPP3_PARBA;  
C1GD57, AMPP3_PARBD;  C0SHQ0, AMPP3_PARBP;  B6H2M0, AMPP3_PENCW;  
B6Q8T5, AMPP3_PENMQ;  Q0U6G5, AMPP3_PHANO;  B2AFW1, AMPP3_PODAN;  
B2WMQ2, AMPP3_PYRTR;  E3S6N7, AMPP3_PYRTT;  A7EUB3, AMPP3_SCLS1;  
D1ZBF6, AMPP3_SORMK;  B8M0Z4, AMPP3_TALSN;  C4JF09, AMPP3_UNCRE;  
C9SEV5, AMPP3_VERA1;  P15034, AMPP_ECOLI;  P44881, AMPP_HAEIN;  
P47566, AMPP_MYCGE;  P75313, AMPP_MYCPN;  Q07825, FRA1_YEAST;  
Q1JPJ2, XPP1_BOVIN;  Q54G06, XPP1_DICDI;  Q9NQW7, XPP1_HUMAN;  
Q6P1B1, XPP1_MOUSE;  O54975, XPP1_RAT;  O43895, XPP2_HUMAN;  
Q95333, XPP2_PIG;  Q54T46, XPP3_DICDI;  Q9NQH7, XPP3_HUMAN;  
B7ZMP1, XPP3_MOUSE;  Q5R9W8, XPP3_PONAB;  B5DEQ3, XPP3_RAT;  

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