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ENZYME entry: EC 3.4.13.21

Accepted Name
Dipeptidase E.
Alternative Name(s)
Aspartyl dipeptidase.
PepE gene product (Salmonella typhimurium).
Peptidase E.
Reaction catalysed
Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides
Comment(s)
  • A free carboxy group is not absolutely required in the substrate since Asp-Phe-NH(2) and Asp-Phe-OMe are hydrolyzed somewhat more slowly than dipeptides with free C-termini.
  • No peptide larger than a C-blocked dipeptide is known to be a substrate.
  • Asp-NH-Np is hydrolyzed and is a convenient substrate for routine assay.
  • The enzyme is most active near pH 7.0, and is not inhibited by di-isopropylfluorophosphate or phenylmethanesulfonyl fluoride.
  • Belongs to peptidase family S51.
Cross-references
BRENDA3.4.13.21
EC2PDB3.4.13.21
ExplorEnz3.4.13.21
PRIAM enzyme-specific profiles3.4.13.21
KEGG Ligand Database for Enzyme Nomenclature3.4.13.21
IUBMB Enzyme Nomenclature3.4.13.21
IntEnz3.4.13.21
MEDLINEFind literature relating to 3.4.13.21
MetaCyc3.4.13.21
UniProtKB/Swiss-Prot
A3N0N1, PEPE_ACTP2;  B3H1L0, PEPE_ACTP7;  B0BPF6, PEPE_ACTPJ;  
A8ANB2, PEPE_CITK8;  Q9VYH3, PEPE_DROME;  A7ZUN5, PEPE_ECO24;  
B7UPH5, PEPE_ECO27;  B7MJ04, PEPE_ECO45;  B7LAW3, PEPE_ECO55;  
P0A7C7, PEPE_ECO57;  B5Z0B3, PEPE_ECO5E;  B7NRV3, PEPE_ECO7I;  
B7MRE6, PEPE_ECO81;  B7M7S7, PEPE_ECO8A;  C5A0V8, PEPE_ECOBW;  
B1XC20, PEPE_ECODH;  A8A7B7, PEPE_ECOHS;  A1AIJ2, PEPE_ECOK1;  
Q0TA47, PEPE_ECOL5;  Q8FB55, PEPE_ECOL6;  B1IUN1, PEPE_ECOLC;  
P0A7C6, PEPE_ECOLI;  B7NFV7, PEPE_ECOLU;  B6I5M9, PEPE_ECOSE;  
B1LPH7, PEPE_ECOSM;  Q1R3S5, PEPE_ECOUT;  Q4QMU5, PEPE_HAEI8;  
A5UHB4, PEPE_HAEIG;  P44766, PEPE_HAEIN;  P58493, PEPE_NOSS1;  
Q9CNH7, PEPE_PASMU;  B5F1K4, PEPE_SALA4;  A9MHB2, PEPE_SALAR;  
Q57H37, PEPE_SALCH;  B5R7Q9, PEPE_SALG2;  B4TDG7, PEPE_SALHS;  
B4T1N0, PEPE_SALNS;  Q5PKZ6, PEPE_SALPA;  A9N1I0, PEPE_SALPB;  
C0Q494, PEPE_SALPC;  B5BJT4, PEPE_SALPK;  B4TQM9, PEPE_SALSV;  
P58494, PEPE_SALTI;  P36936, PEPE_SALTY;  A1S5J3, PEPE_SHEAM;  
B8E718, PEPE_SHEB2;  A3D5N8, PEPE_SHEB5;  A6WPJ2, PEPE_SHEB8;  
A9L579, PEPE_SHEB9;  Q12MB3, PEPE_SHEDO;  Q8EDL3, PEPE_SHEON;  
A4Y7X3, PEPE_SHEPC;  A0KY73, PEPE_SHESA;  Q0HHP4, PEPE_SHESM;  
Q0HTZ6, PEPE_SHESR;  A1RIL5, PEPE_SHESW;  B2TX41, PEPE_SHIB3;  
Q31TY2, PEPE_SHIBS;  Q0SXY7, PEPE_SHIF8;  Q83PB5, PEPE_SHIFL;  
Q3YUW9, PEPE_SHISS;  Q93RZ5, PEPE_STRCO;  Q91642, PEPE_XENLA;  

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