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ENZYME entry: EC 188.8.131.52
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|D-Ala-D-Ala + H(2)O <=> 2 D-Ala|
- Protects Enterococcus faecium from the antibiotic vancomycin, which
can bind to the -D-Ala-D-Ala sequence at the C-terminus of the
- Reduces the availability of the free dipeptide D-Ala-D-Ala, which is
the precursor for this pentapeptide sequence, allowing D-Ala-(R)-
lactate (for which vancomycin has much less affinity) to be added to
the cell wall instead.
- The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-
D-Ala are not substrates.
- Belongs to peptidase family M15.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
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entries corresponding to 3.4.13.-
entries corresponding to 3.4.-.-
entries corresponding to 3.-.-.-