ENZYME entry: EC 3.4.13.22

Accepted Name
D-Ala-D-Ala dipeptidase.
Alternative Name(s)
D-alanyl-D-alanine dipeptidase.
Reaction catalysed
D-Ala-D-Ala + H(2)O <=> 2 D-Ala
Cofactor(s)
Zn(2+).
Comment(s)
  • Protects Enterococcus faecium from the antibiotic vancomycin, which can bind to the -D-Ala-D-Ala sequence at the C-terminus of the peptidoglycan pentapeptide.
  • Reduces the availability of the free dipeptide D-Ala-D-Ala, which is the precursor for this pentapeptide sequence, allowing D-Ala-(R)- lactate (for which vancomycin has much less affinity) to be added to the cell wall instead.
  • The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala- D-Ala are not substrates.
  • Belongs to peptidase family M15.
Cross-references
BRENDA3.4.13.22
EC2PDB3.4.13.22
ExplorEnz3.4.13.22
PRIAM enzyme-specific profiles3.4.13.22
KEGG Ligand Database for Enzyme Nomenclature3.4.13.22
IUBMB Enzyme Nomenclature3.4.13.22
IntEnz3.4.13.22
MEDLINEFind literature relating to 3.4.13.22
MetaCyc3.4.13.22
UniProtKB/Swiss-Prot
P77790, DDPX_ECOLI;  P74268, DDPX_SYNY3;  Q47749, VANX_ENTFA;  
Q06241, VANX_ENTFC;  Q9XAK6, VANX_STRCO;  

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