ID   3.4.13.22
DE   D-Ala-D-Ala dipeptidase.
AN   D-alanyl-D-alanine dipeptidase.
CA   D-alanyl-D-alanine + H2O = 2 D-alanine.
CC   -!- Protects Enterococcus faecium from the antibiotic vancomycin, which
CC       can bind to the -D-Ala-D-Ala sequence at the C-terminus of the
CC       peptidoglycan pentapeptide.
CC   -!- Reduces the availability of the free dipeptide D-Ala-D-Ala, which is
CC       the precursor for this pentapeptide sequence, allowing D-Ala-(R)-
CC       lactate (for which vancomycin has much less affinity) to be added to
CC       the cell wall instead.
CC   -!- The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-
CC       D-Ala are not substrates.
CC   -!- Belongs to peptidase family M15.
DR   P77790, DDPX_ECOLI ;  P74268, DDPX_SYNY3 ;  Q47749, VANX_ENTFA ;
DR   Q06241, VANX_ENTFC ;  Q9XAK6, VANX_STRCO ;
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