ENZYME entry: EC 3.4.13.9

Accepted Name
Xaa-Pro dipeptidase.
Alternative Name(s)
Gamma-peptidase.
Imidodipeptidase.
Peptidase D.
Prolidase.
Proline dipeptidase.
X-Pro dipeptidase.
Reaction catalysed
Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro
Cofactor(s)
Manganese.
Comment(s)
  • Possibly thiol dependent.
  • Cytosolic from most animal tissues.
  • Belongs to peptidase family M24A.
  • Formerly EC 3.4.3.7.
Cross-references
PROSITEPDOC00417
BRENDA3.4.13.9
EC2PDB3.4.13.9
ExplorEnz3.4.13.9
PRIAM enzyme-specific profiles3.4.13.9
KEGG Ligand Database for Enzyme Nomenclature3.4.13.9
IUBMB Enzyme Nomenclature3.4.13.9
IntEnz3.4.13.9
MEDLINEFind literature relating to 3.4.13.9
MetaCyc3.4.13.9
UniProtKB/Swiss-Prot
Q55E60, PEPD_DICDI;  P12955, PEPD_HUMAN;  Q11136, PEPD_MOUSE;  
Q5RFB3, PEPD_PONAB;  Q5I0D7, PEPD_RAT;  Q5QXH5, PEPQ1_IDILO;  
Q5QVP2, PEPQ2_IDILO;  A3MYG3, PEPQ_ACTP2;  B3GZT0, PEPQ_ACTP7;  
A0KEL3, PEPQ_AERHH;  A4STF0, PEPQ_AERS4;  Q44238, PEPQ_ALTSX;  
A8ACZ6, PEPQ_CITK8;  Q48AT5, PEPQ_COLP3;  A7MQN9, PEPQ_CROS8;  
A7ZU52, PEPQ_ECO24;  B7UNH5, PEPQ_ECO27;  B7MHD2, PEPQ_ECO45;  
B7L9A5, PEPQ_ECO55;  Q8X8I1, PEPQ_ECO57;  B5YY94, PEPQ_ECO5E;  
B7NV19, PEPQ_ECO7I;  B7N2F3, PEPQ_ECO81;  B7M650, PEPQ_ECO8A;  
C5A021, PEPQ_ECOBW;  B1XAK9, PEPQ_ECODH;  A8A6V2, PEPQ_ECOHS;  
A1AI34, PEPQ_ECOK1;  Q0TAK9, PEPQ_ECOL5;  Q8FBI1, PEPQ_ECOL6;  
B1IW60, PEPQ_ECOLC;  P21165, PEPQ_ECOLI;  B7NFE8, PEPQ_ECOLU;  
B6I4I7, PEPQ_ECOSE;  B1LM33, PEPQ_ECOSM;  Q1R465, PEPQ_ECOUT;  
C5BCB6, PEPQ_EDWI9;  A4WFX3, PEPQ_ENT38;  B2VFE3, PEPQ_ERWT9;  
B7LTY8, PEPQ_ESCF3;  B8F8H3, PEPQ_HAEPS;  Q2S6U2, PEPQ_HAHCH;  
B5XYG9, PEPQ_KLEP3;  A6TGM5, PEPQ_KLEP7;  Q9S6S1, PEPQ_LACDE;  
P46545, PEPQ_LACDL;  O84913, PEPQ_LACHE;  A1TXT7, PEPQ_MARAV;  
Q6DAP4, PEPQ_PECAS;  C6DI64, PEPQ_PECCP;  Q7MZ93, PEPQ_PHOLL;  
B4EWE3, PEPQ_PROMH;  Q15ZF7, PEPQ_PSEA6;  P77814, PEPQ_PSEHA;  
Q3IJ21, PEPQ_PSEHT;  P81535, PEPQ_PYRFU;  O58885, PEPQ_PYRHO;  
B5EZW1, PEPQ_SALA4;  A9MIX1, PEPQ_SALAR;  Q57HM5, PEPQ_SALCH;  
B5FNX9, PEPQ_SALDC;  B5QW86, PEPQ_SALEP;  B5RFL5, PEPQ_SALG2;  
B4TBS6, PEPQ_SALHS;  B4SZ86, PEPQ_SALNS;  Q5PKQ1, PEPQ_SALPA;  
A9MYB1, PEPQ_SALPB;  C0Q3F4, PEPQ_SALPC;  B5BIZ1, PEPQ_SALPK;  
B4TNZ2, PEPQ_SALSV;  Q9L6L4, PEPQ_SALTI;  Q7CPD4, PEPQ_SALTY;  
A8G8D3, PEPQ_SERP5;  A1S1I9, PEPQ_SHEAM;  B8E3R4, PEPQ_SHEB2;  
A3CYJ5, PEPQ_SHEB5;  A6WHA1, PEPQ_SHEB8;  A9KU92, PEPQ_SHEB9;  
Q12TB3, PEPQ_SHEDO;  Q08A38, PEPQ_SHEFN;  B0TLC0, PEPQ_SHEHH;  
A3Q8U5, PEPQ_SHELP;  Q8EKR8, PEPQ_SHEON;  A8GYG1, PEPQ_SHEPA;  
A4Y1B7, PEPQ_SHEPC;  B8CHA2, PEPQ_SHEPW;  A0KR51, PEPQ_SHESA;  
A8FP64, PEPQ_SHESH;  Q0HPB6, PEPQ_SHESM;  Q0I0T2, PEPQ_SHESR;  
A1RDW7, PEPQ_SHESW;  B1KCZ4, PEPQ_SHEWM;  B2TVJ6, PEPQ_SHIB3;  
Q31UE2, PEPQ_SHIBS;  Q32A22, PEPQ_SHIDS;  Q0SZ37, PEPQ_SHIF8;  
Q83PG0, PEPQ_SHIFL;  Q3YVC0, PEPQ_SHISS;  Q2NWT2, PEPQ_SODGM;  
B4SI11, PEPQ_STRM5;  B2FT23, PEPQ_STRMK;  Q8PH57, PEPQ_XANAC;  
Q3BPR2, PEPQ_XANC5;  Q4UY33, PEPQ_XANC8;  B0RP90, PEPQ_XANCB;  
Q8P5S9, PEPQ_XANCP;  Q2P6N8, PEPQ_XANOM;  Q5H3T0, PEPQ_XANOR;  
A1JIG5, PEPQ_YERE8;  A7FDF3, PEPQ_YERP3;  Q1C2C5, PEPQ_YERPA;  
B2K0Z7, PEPQ_YERPB;  Q0WAP4, PEPQ_YERPE;  A9R755, PEPQ_YERPG;  
Q1CN98, PEPQ_YERPN;  A4TR26, PEPQ_YERPP;  Q66FR7, PEPQ_YERPS;  
B1JP62, PEPQ_YERPY;  

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