ENZYME

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ENZYME entry: EC 3.4.14.12

Accepted Name

Xaa-Xaa-Pro tripeptidyl-peptidase.

Alternative Name(s)

Prolyl tripeptidyl peptidase.

Prolyltripeptidyl amino peptidase.

Prolyltripeptidyl aminopeptidase.

PTP-A.

TPP.

Reaction catalysed

Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline

Comment(s)

This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium Porphyromonas gingivalis, which has been implicated in adult periodontal disease.
The enzyme releases tripeptides from the free amino terminus of peptides and small proteins, such as interleukin-6.
The enzyme possesses an absolute requirement for a proline residue at the P1 position but is completely inactivated by a proline residue at the P1' position.
The size of the peptide does not affect the rate of reaction.

Cross-references

BRENDA

3.4.14.12

EC2PDB

3.4.14.12

ExplorEnz

3.4.14.12

PRIAM enzyme-specific profiles

3.4.14.12

KEGG Ligand Database for Enzyme Nomenclature

3.4.14.12

IUBMB Enzyme Nomenclature