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ENZYME entry: EC

Accepted Name
Xaa-Xaa-Pro tripeptidyl-peptidase.
Alternative Name(s)
Prolyl tripeptidyl peptidase.
Prolyltripeptidyl amino peptidase.
Prolyltripeptidyl aminopeptidase.
Reaction catalysed
Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a peptide with Pro as the third residue (position P1) and where Yaa is not proline
  • This cell-surface-associated serine exopeptidase is found in the Gram-negative, anaerobic bacterium Porphyromonas gingivalis, which has been implicated in adult periodontal disease.
  • The enzyme releases tripeptides from the free amino terminus of peptides and small proteins, such as interleukin-6.
  • The enzyme possesses an absolute requirement for a proline residue at the P1 position but is completely inactivated by a proline residue at the P1' position.
  • The size of the peptide does not affect the rate of reaction.
PRIAM enzyme-specific profiles3.4.14.12
KEGG Ligand Database for Enzyme Nomenclature3.4.14.12
IUBMB Enzyme Nomenclature3.4.14.12
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