ID   3.4.14.12
DE   Xaa-Xaa-Pro tripeptidyl-peptidase.
AN   prolyltripeptidyl aminopeptidase.
AN   prolyltripeptidyl amino peptidase.
AN   prolyl tripeptidyl peptidase.
AN   PTP-A.
AN   TPP.
CA   Hydrolysis of Xaa-Xaa-Pro-|-Yaa- releasing the N-terminal tripeptide of a
CA   peptide with Pro as the third residue (position P1) and where Yaa is not
CA   proline.
CC   -!- This cell-surface-associated serine exopeptidase is found in the
CC       Gram-negative, anaerobic bacterium Porphyromonas gingivalis, which
CC       has been implicated in adult periodontal disease.
CC   -!- The enzyme releases tripeptides from the free amino terminus of
CC       peptides and small proteins, such as interleukin-6.
CC   -!- The enzyme possesses an absolute requirement for a proline residue at
CC       the P1 position but is completely inactivated by a proline residue at
CC       the P1' position.
CC   -!- The size of the peptide does not affect the rate of reaction.
DR   B2RJX3, PTP_PORG3  ;  Q7MUW6, PTP_PORGI  ;
//