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ENZYME entry: EC 3.4.14.5

Accepted Name
Dipeptidyl-peptidase IV.
Alternative Name(s)
Dipeptidyl aminopeptidase IV.
DPP IV.
Gly-Pro naphthylamidase.
Post-proline dipeptidyl aminopeptidase IV.
Xaa-Pro-dipeptidylaminopeptidase.
Reaction catalysed
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
Comment(s)
  • A membrane-bound serine-type peptidase in mammals.
  • EC 3.4.14.11 catalyzes a similar reaction.
  • Belongs to peptidase family S9B.
Cross-references
PROSITEPDOC00587
BRENDA3.4.14.5
EC2PDB3.4.14.5
ExplorEnz3.4.14.5
PRIAM enzyme-specific profiles3.4.14.5
KEGG Ligand Database for Enzyme Nomenclature3.4.14.5
IUBMB Enzyme Nomenclature3.4.14.5
IntEnz3.4.14.5
MEDLINEFind literature relating to 3.4.14.5
MetaCyc3.4.14.5
UniProtKB/Swiss-Prot
Q6F3I7, DAP4_PSEMX;  F0U7H7, DAPB_AJEC8;  C0NUQ8, DAPB_AJECG;  
C6HRC7, DAPB_AJECH;  A6RBI0, DAPB_AJECN;  C5GVF3, DAPB_AJEDR;  
C5JC30, DAPB_AJEDS;  D4AQT0, DAPB_ARTBC;  E4UYL6, DAPB_ARTGP;  
C5FYZ3, DAPB_ARTOC;  A1CJQ1, DAPB_ASPCL;  B0XYK8, DAPB_ASPFC;  
B8N076, DAPB_ASPFN;  Q4WX13, DAPB_ASPFU;  A2QEK7, DAPB_ASPNC;  
Q96VT7, DAPB_ASPNG;  Q2UPW4, DAPB_ASPOR;  Q0CXB1, DAPB_ASPTN;  
A6SL49, DAPB_BOTFB;  Q2HF90, DAPB_CHAGB;  C5P334, DAPB_COCP7;  
E9CUF4, DAPB_COCPS;  E3QKD2, DAPB_COLGM;  Q5B934, DAPB_EMENI;  
F0XS04, DAPB_GROCL;  A4QYQ5, DAPB_MAGO7;  E9ED72, DAPB_METAQ;  
E9ETL5, DAPB_METRA;  C7YYG9, DAPB_NECH7;  A1D7R6, DAPB_NEOFI;  
Q7SHU8, DAPB_NEUCR;  C1GT79, DAPB_PARBA;  C1FZL3, DAPB_PARBD;  
C0S7H1, DAPB_PARBP;  B6HFS8, DAPB_PENRW;  Q0UVK7, DAPB_PHANO;  
B2A951, DAPB_PODAN;  B2WC36, DAPB_PYRTR;  E3S9K3, DAPB_PYRTT;  
A7EQZ1, DAPB_SCLS1;  D1Z9B4, DAPB_SORMK;  B6QVW4, DAPB_TALMQ;  
B8MTH6, DAPB_TALSN;  D4DCG0, DAPB_TRIVH;  D5GM60, DAPB_TUBMM;  
C4JHY5, DAPB_UNCRE;  C9SJ15, DAPB_VERA1;  D4APE2, DPP4_ARTBC;  
C5FJE3, DPP4_ARTOC;  A0S5V9, DPP4_ARTOT;  A1CHP1, DPP4_ASPCL;  
B0Y6C5, DPP4_ASPFC;  B8N970, DPP4_ASPFN;  Q4WPH9, DPP4_ASPFU;  
Q2UH35, DPP4_ASPOR;  P81425, DPP4_BOVIN;  Q5AZ42, DPP4_EMENI;  
Q9N2I7, DPP4_FELCA;  P27487, DPP4_HUMAN;  P28843, DPP4_MOUSE;  
A1CX29, DPP4_NEOFI;  P22411, DPP4_PIG;  P14740, DPP4_RAT;  
A7UKV8, DPP4_TRIEQ;  Q5J6J3, DPP4_TRIRU;  B6V868, DPP4_TRITO;  
D4CZ59, DPP4_TRIVH;  Q6V1X1, DPP8_HUMAN;  Q80YA7, DPP8_MOUSE;  
Q86TI2, DPP9_HUMAN;  Q8BVG4, DPP9_MOUSE;  A5D7B7, SEPR_BOVIN;  
Q12884, SEPR_HUMAN;  P97321, SEPR_MOUSE;  B1A4F7, VDDP4_VESVU;  
B2D0J4, VDPP4_APIME;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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