ENZYME entry: EC 3.4.16.4

Accepted Name
Serine-type D-Ala-D-Ala carboxypeptidase.
Alternative Name(s)
D-alanyl-D-alanine carboxypeptidase.
DD-peptidase.
DD-transpeptidase.
Reaction catalysed
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
Comment(s)
  • A group of bacterial enzymes, membrane-bound.
  • Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme.
  • Distinct from EC 3.4.17.14.
  • Belongs to peptidase families S11, S12 and S13.
Cross-references
BRENDA3.4.16.4
EC2PDB3.4.16.4
ExplorEnz3.4.16.4
PRIAM enzyme-specific profiles3.4.16.4
KEGG Ligand Database for Enzyme Nomenclature3.4.16.4
IUBMB Enzyme Nomenclature3.4.16.4
IntEnz3.4.16.4
MEDLINEFind literature relating to 3.4.16.4
MetaCyc3.4.16.4
UniProtKB/Swiss-Prot
P08750, DACA_BACSU;  P0AEB4, DACA_ECO57;  P0AEB3, DACA_ECOL6;  
P0AEB2, DACA_ECOLI;  Q05523, DACA_GEOSE;  P44466, DACA_HAEIN;  
P35150, DACB_BACSU;  P24228, DACB_ECOLI;  P45161, DACB_HAEIN;  
P39844, DACC_BACSU;  P08506, DACC_ECOLI;  P33013, DACD_ECOLI;  
P37604, DACD_SALTY;  P38422, DACF_BACSU;  P39042, DACX_STRSK;  
P39045, DAC_ACTSP;  P15555, DAC_STRSR;  Q86I79, PSCA_DICDI;  
Q47746, VANY_ENTFA;  P37711, VANY_ENTFC;  

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